Depression, anxiety, and health-related quality of life in normal weight, overweight and obese individuals with diabetes: a representative study in Germany.

Anxiety Depression Diabetes Health-related quality of life Obesity

Journal

Acta diabetologica
ISSN: 1432-5233
Titre abrégé: Acta Diabetol
Pays: Germany
ID NLM: 9200299

Informations de publication

Date de publication:
02 Mar 2024
Historique:
received: 17 08 2023
accepted: 29 01 2024
medline: 2 3 2024
pubmed: 2 3 2024
entrez: 2 3 2024
Statut: aheadofprint

Résumé

Diabetes in the course of lifetime is related to a higher risk for mental disorders. The present study addresses the comparison of individuals with diabetes and non-diabetic individuals in depressive symptoms, generalized anxiety symptoms, and health-related quality of life. Furthermore, mediator effect of BMI and health-related quality of life (HRQOL) on the association between diabetes, depression, and generalized anxiety was analyzed. In this cross-sectional study, the three questionnaires PHQ-9, GAD-7, EQ-5D-5L were measured in a representative sample of the German population (N = 2386). In addition, the presence of diabetes and BMI were assessed via self-report. There were higher values in depressive and anxiety symptoms as well as lower score in HRQOL in individuals with diabetes compared to non-diabetic individuals. Obese individuals with diabetes showed the highest rates in depressive symptoms and generalized anxiety as well as lowest score in HRQOL. With regard to the mediator analyses, association between diabetes, depressive symptoms, and anxiety symptoms is partially mediated by the BMI and fully mediated by the HRQOL. In conclusion, individuals with diabetes have an increased risk in the development of depressive and anxiety symptoms as well as lower health-related quality of life. Future research and strategies in the public health policies among individuals with diabetes should take into account that the association between diabetes, depression, and anxiety is mediated by BMI and HRQOL.

Identifiants

pubmed: 38430257
doi: 10.1007/s00592-024-02248-7
pii: 10.1007/s00592-024-02248-7
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

Références

Rosenbauer J, Neu A, Rothe U et al (2019) Types of diabetes are not limited to age groups: type 1 diabetes in adults and type 2 diabetes in children and adolescents. J Health Monit 4:29–49. https://doi.org/10.25646/5987
doi: 10.25646/5987 pubmed: 35146246 pmcid: 8822252
Tönnies T, Röckl S, Hoyer A et al (2019) Projected number of people with diagnosed Type 2 diabetes in Germany in 2040. Diabet Med 36:1217–1225. https://doi.org/10.1111/dme.13902
doi: 10.1111/dme.13902 pubmed: 30659656
Saeedi P, Petersohn I, Salpea P et al (2019) Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atla, 9th edition. Diabetes Res Clin Pract 157:107843. https://doi.org/10.1016/j.diabres.2019.107843
doi: 10.1016/j.diabres.2019.107843 pubmed: 31518657
Sagoo MK, Gnudi L (2020) Diabetic nephropathy: an overview. pp 3–7
Glovaci D, Fan W, Wong ND (2019) Epidemiology of diabetes mellitus and cardiovascular disease. Curr Cardiol Rep 21:21. https://doi.org/10.1007/s11886-019-1107-y
doi: 10.1007/s11886-019-1107-y pubmed: 30828746
Roy T, Lloyd CE (2012) Epidemiology of depression and diabetes: a systematic review. J Affect Disord 142:S8–S21. https://doi.org/10.1016/S0165-0327(12)70004-6
doi: 10.1016/S0165-0327(12)70004-6 pubmed: 23062861
Collins MM, Corcoran P, Perry IJ (2009) Anxiety and depression symptoms in patients with diabetes. Diabet Med 26:153–161. https://doi.org/10.1111/j.1464-5491.2008.02648.x
doi: 10.1111/j.1464-5491.2008.02648.x pubmed: 19236618
Rotella F, Mannucci E (2013) Depression as a risk factor for diabetes. J Clin Psychiatry 74:31–37. https://doi.org/10.4088/JCP.12r07922
doi: 10.4088/JCP.12r07922 pubmed: 23419223
Bergmans RS, Rapp A, Kelly KM et al (2021) Understanding the relationship between type 2 diabetes and depression: lessons from genetically informative study designs. Diabet Med. https://doi.org/10.1111/dme.14399
doi: 10.1111/dme.14399 pubmed: 32924175
Amiri S, Behnezhad S (2019) Diabetes and anxiety symptoms: A systematic review and meta-analysis. Int J Psychiatry Med. https://doi.org/10.1177/0091217419837407
doi: 10.1177/0091217419837407 pubmed: 31060410
Smith KJ, Béland M, Clyde M et al (2013) Association of diabetes with anxiety: a systematic review and meta-analysis. J Psychosom Res 74:89–99. https://doi.org/10.1016/j.jpsychores.2012.11.013
doi: 10.1016/j.jpsychores.2012.11.013 pubmed: 23332522
Smith KJ, Deschênes SS, Schmitz N (2018) Investigating the longitudinal association between diabetes and anxiety: a systematic review and meta-analysis. Diabet Med 35:677–693. https://doi.org/10.1111/dme.13606
doi: 10.1111/dme.13606 pubmed: 29460506 pmcid: 5969311
Busutil R, Espallardo O, Torres A et al (2017) The impact of obesity on health-related quality of life in Spain. Health Qual Life Outcomes 15:197. https://doi.org/10.1186/s12955-017-0773-y
doi: 10.1186/s12955-017-0773-y pubmed: 29017494 pmcid: 5634835
Herhaus B, Kersting A, Brähler E, Petrowski K (2020) Depression, anxiety and health status across different BMI classes: a representative study in Germany. J Affect Disord 276:45–52. https://doi.org/10.1016/j.jad.2020.07.020
doi: 10.1016/j.jad.2020.07.020 pubmed: 32697715
Atasoy S, Johar H, Fang XY et al (2018) Cumulative effect of depressed mood and obesity on type II diabetes incidence: findings from the MONICA/KORA cohort study. J Psychosom Res 115:66–70. https://doi.org/10.1016/j.jpsychores.2018.10.007
doi: 10.1016/j.jpsychores.2018.10.007 pubmed: 30470320
Badawi G, Pagé V, Smith KJ et al (2013) Self-rated health: a predictor for the three year incidence of major depression in individuals with Type II diabetes. J Affect Disord 145:100–105. https://doi.org/10.1016/j.jad.2012.07.018
doi: 10.1016/j.jad.2012.07.018 pubmed: 22902269
Bashkin O, Horne R, Bridevaux IP (2018) Influence of health status on the association between diabetes and depression among adults in Europe: findings from the SHARE international survey. Diabet Spectr 31:75–82. https://doi.org/10.2337/ds16-0063
doi: 10.2337/ds16-0063
Fakhri M, Abdan M, Ramezanpour M et al (2021) Systematic review and meta-analysis on quality of life in diabetic patients in Iran. Int J Prev Med 12:41. https://doi.org/10.4103/ijpvm.IJPVM_327_19
doi: 10.4103/ijpvm.IJPVM_327_19 pubmed: 34211672 pmcid: 8223913
Liu X, Haagsma J, Sijbrands E et al (2020) Anxiety and depression in diabetes care: longitudinal associations with health-related quality of life. Sci Rep 10:8307. https://doi.org/10.1038/s41598-020-57647-x
doi: 10.1038/s41598-020-57647-x pubmed: 32433470 pmcid: 7239869
Asman AG, Hoogendoorn CJ, McKee MD, Gonzalez JS (2020) Assessing the association of depression and anxiety with symptom reporting among individuals with type 2 diabetes. J Behav Med 43:57–68. https://doi.org/10.1007/s10865-019-00056-x
doi: 10.1007/s10865-019-00056-x pubmed: 31111355
Barnes AS (2011) The epidemic of obesity and diabetes: trends and treatments. Tex Heart Inst J 38:142–144
pubmed: 21494521 pmcid: 3066828
Anderson RJ, Freedland KE, Clouse RE, Lustman PJ (2001) The prevalence of comorbid depression in adults with diabetes. Diabetes Care 24:1069–1078. https://doi.org/10.2337/diacare.24.6.1069
doi: 10.2337/diacare.24.6.1069 pubmed: 11375373
Wendt AA-S (1994) Das ADM-stichproben-system stand: 1993. In: Gabler S, Hoffmeyer-Zlotnik JH, Krebs D (eds) Gewichtung in der Umfragepraxis. Westdeutscher Verlag, Opladen, pp 188–202
Löwe B, Spitzer RL, Zipfel S, Herzog W (2002) Gesundheitsfragebogen für Patienten (PHQ-D). Manual und Testunterlagen (2. Auflage). Pfizer, Karlsruhe
Spitzer RL, Kroenke K, Williams JBW, Löwe B (2006) A brief measure for assessing generalized anxiety disorder. Arch Intern Med 166:1092. https://doi.org/10.1001/archinte.166.10.1092
doi: 10.1001/archinte.166.10.1092 pubmed: 16717171
Herdman M, Gudex C, Lloyd A et al (2011) Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L). Qual Life Res 20:1727–1736. https://doi.org/10.1007/s11136-011-9903-x
doi: 10.1007/s11136-011-9903-x pubmed: 21479777 pmcid: 3220807
Hinz A, Kohlmann T, Stöbel-Richter Y et al (2014) The quality of life questionnaire EQ-5D-5L: psychometric properties and normative values for the general German population. Qual Life Res 23:443–447. https://doi.org/10.1007/s11136-013-0498-2
doi: 10.1007/s11136-013-0498-2 pubmed: 23921597
Cheung PWH, Wong CKH, Samartzis D et al (2016) Psychometric validation of the EuroQoL 5-Dimension 5-Level (EQ-5D-5L) in Chinese patients with adolescent idiopathic scoliosis. Scoliosis Spinal Disord 11:19. https://doi.org/10.1186/s13013-016-0083-x
doi: 10.1186/s13013-016-0083-x pubmed: 27525314 pmcid: 4973368
Yfantopoulos JN, Chantzaras AE (2017) Validation and comparison of the psychometric properties of the EQ-5D-3L and EQ-5D-5L instruments in Greece. Eur J Health Econ 18:519–531. https://doi.org/10.1007/s10198-016-0807-0
doi: 10.1007/s10198-016-0807-0 pubmed: 27262480
Schmalbach B, Zenger M, Brähler E, Petrowski K (2020) Norm values and psychometric properties for the German health regulatory focus scale—results of a representative survey. BMC Med Res Methodol 20:51. https://doi.org/10.1186/s12874-020-00927-x
doi: 10.1186/s12874-020-00927-x pubmed: 32122330 pmcid: 7053077
Hayes AF (2018) Introduction to mediation, moderation, and conditional process analysis, (methodology in the social sciences), 2nd edn. Guilford Press, New York
Davidson R, MacKinnon JG (1993) Estimation and Inference in Econometrics. Oxford University Press, Oxford
Kocalevent RD, Hinz A, Brähler E (2013) Standardization of the depression screener patient health questionnaire (PHQ-9) in the general population. Gen Hosp Psychiatry 35:551–555. https://doi.org/10.1016/j.genhosppsych.2013.04.006
doi: 10.1016/j.genhosppsych.2013.04.006 pubmed: 23664569
Kroenke K, Spitzer RL, Williams JB (2001) The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med 16:606–613
doi: 10.1046/j.1525-1497.2001.016009606.x pubmed: 11556941 pmcid: 1495268
Holt RIG, de Groot M, Golden SH (2014) Diabetes and Depression. Curr Diab Rep 14:491. https://doi.org/10.1007/s11892-014-0491-3
doi: 10.1007/s11892-014-0491-3 pubmed: 24743941 pmcid: 4476048
Nouwen A, Nefs G, Caramlau I et al (2011) Prevalence of depression in individuals with impaired glucose metabolism or undiagnosed diabetes: a systematic review and meta-analysis of the European Depression in Diabetes (EDID) Research Consortium. Diabetes Care 34:752–762. https://doi.org/10.2337/dc10-1414
doi: 10.2337/dc10-1414 pubmed: 21357362 pmcid: 3041222
Benton M, Silverio SA, Ismail K (2023) “It feels like medically promoted disordered eating”: The psychosocial impact of gestational diabetes mellitus in the perinatal period. PLoS ONE 18:e0288395. https://doi.org/10.1371/journal.pone.0288395
doi: 10.1371/journal.pone.0288395 pubmed: 37478148 pmcid: 10361484
Pérez-Fernández A, Fernández-Berrocal P, Gutiérrez-Cobo MJ (2023) The relationship between well-being and HbA1c in adults with type 1 diabetes: a systematic review. J Diabetes 15:152–164. https://doi.org/10.1111/1753-0407.13357
doi: 10.1111/1753-0407.13357 pubmed: 36796311 pmcid: 9934956
Kalra S, Jena B, Yeravdekar R (2018) Emotional and psychological needs of people with diabetes. Indian J Endocrinol Metab 22:696. https://doi.org/10.4103/ijem.IJEM_579_17
doi: 10.4103/ijem.IJEM_579_17 pubmed: 30294583 pmcid: 6166557
Svenningsson I, Björkelund C, Marklund B, Gedda B (2012) Anxiety and depression in obese and normal-weight individuals with diabetes type 2: a gender perspective. Scand J Caring Sci 26:349–354. https://doi.org/10.1111/j.1471-6712.2011.00940.x
doi: 10.1111/j.1471-6712.2011.00940.x pubmed: 22077658
Wiltink J, Michal M, Wild PS et al (2014) Associations between depression and diabetes in the community: do symptom dimensions matter? results from the Gutenberg health study. PLoS ONE 9:e105499. https://doi.org/10.1371/journal.pone.0105499
doi: 10.1371/journal.pone.0105499 pubmed: 25127227 pmcid: 4134314
Hsieh H-M, Lin C-H, Weng S-F et al (2023) Health-related quality of life, medical resource use and physical function in patients with diabetes mellitus and depression: a cross-sectional analysis from the National Health and Nutrition Examination Survey. J Affect Disord 327:93–100. https://doi.org/10.1016/j.jad.2023.02.011
doi: 10.1016/j.jad.2023.02.011 pubmed: 36754091
Wang L, Yan N, Guo R et al (2022) Mediating role of depressive symptoms on the association between neighborhood social cohesion and quality of life in individuals with type 2 diabetes mellitus. Patient Prefer Adherence 16:1085–1092. https://doi.org/10.2147/PPA.S354181
doi: 10.2147/PPA.S354181 pubmed: 35479653 pmcid: 9037707
Löwe B, Decker O, Müller S et al (2008) Validation and standardization of the generalized anxiety disorder screener (GAD-7) in the general population. Med Care 46:266–274. https://doi.org/10.1097/MLR.0b013e318160d093
doi: 10.1097/MLR.0b013e318160d093 pubmed: 18388841
Vogelzangs N, Beekman ATF, de Jonge P, Penninx BWJH (2013) Anxiety disorders and inflammation in a large adult cohort. Transl Psychiatry 3:e249–e249. https://doi.org/10.1038/tp.2013.27
doi: 10.1038/tp.2013.27 pubmed: 23612048 pmcid: 3641413
Luca L, Nemeroff CB (2015) The role of the hypothalamic–pituitary–adrenal axis in anxiety disorders. In: Anxiety disorders. Oxford University Press, pp 401–412
Tsalamandris S, Antonopoulos AS, Oikonomou E et al (2019) The role of inflammation in diabetes: current concepts and future perspectives. Eur Cardiol 14:50–59. https://doi.org/10.15420/ecr.2018.33.1
doi: 10.15420/ecr.2018.33.1 pubmed: 31131037 pmcid: 6523054
Hossain S, Anjum A, Hasan MT et al (2020) Self-perception of physical health conditions and its association with depression and anxiety among Bangladeshi university students. J Affect Disord 263:282–288. https://doi.org/10.1016/j.jad.2019.11.153
doi: 10.1016/j.jad.2019.11.153 pubmed: 31818790

Auteurs

Benedict Herhaus (B)

Medical Psychology and Medical Sociology, University Medical Center Mainz, Johannes Gutenberg University of Mainz, Duesbergweg 6, 55128, Mainz, Germany. bherhaus@uni-mainz.de.

Johannes Kruse (J)

Department of Psychosomatic Medicine and Psychotherapy, Philipps University Marburg, Marburg, Germany.
Department of Psychosomatic Medicine and Psychotherapy, Justus Liebig University Giessen, Giessen, Germany.

Andreas Hinz (A)

Department of Medical Psychology and Medical Sociology, University of Leipzig, Leipzig, Germany.

Elmar Brähler (E)

Integrated Research and Treatment Center Adiposity Diseases, Behavioral Medicine Unit, Department of Psychosomatic Medicine and Psychotherapy, Leipzig University Medical Center, Leipzig, Germany.
Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, Johannes Gutenberg University Mainz, Mainz, Germany.

Katja Petrowski (K)

Medical Psychology and Medical Sociology, University Medical Center Mainz, Johannes Gutenberg University of Mainz, Duesbergweg 6, 55128, Mainz, Germany.

Classifications MeSH