Quantification of Solid Embryonic Cerebellar Graft Volume in a Degenerative Ataxia Model.
Cerebellum
Lurcher mice
Neurotransplantation
Olivocerebellar degeneration
Journal
Cerebellum (London, England)
ISSN: 1473-4230
Titre abrégé: Cerebellum
Pays: United States
ID NLM: 101089443
Informations de publication
Date de publication:
02 Mar 2024
02 Mar 2024
Historique:
accepted:
23
02
2024
medline:
2
3
2024
pubmed:
2
3
2024
entrez:
2
3
2024
Statut:
aheadofprint
Résumé
Substitution of lost neurons by neurotransplantation would be a possible management of advanced degenerative cerebellar ataxias in which insufficient cerebellar reserve remains. In this study, we examined the volume and structure of solid embryonic cerebellar grafts in adult Lurcher mice, a model of olivocerebellar degeneration, and their healthy littermates. Grafts taken from enhanced green fluorescent protein (EGFP)-positive embryos were injected into the cerebellum of host mice. Two or six months later, the brains were examined histologically. The grafts were identified according to the EGFP fluorescence in frozen sections and their volumes were estimated using the Cavalieri principle. For gross histological evaluation, graft-containing slices were processed using Nissl and hematoxylin-eosin staining. Adjustment of the volume estimation approach suggested that it is reasonable to use all sections without sampling, but that calculation of values for up to 20% of lost section using linear interpolation does not constitute substantial error. Mean graft volume was smaller in Lurchers than in healthy mice when examined 6 months after the transplantation. We observed almost no signs of graft destruction. In some cases, compact grafts disorganized the structure of the host's cerebellar cortex. In Lurchers, the grafts had a limited contact with the host's cerebellum. Also, graft size was of greater variability in Lurchers than in healthy mice. The results are in compliance with our previous findings that Lurcher phenotype-associated factors have a negative effect on graft development. These factors can hypothetically include cerebellar morphology, local tissue milieu, or systemic factors such as immune system abnormalities.
Identifiants
pubmed: 38430389
doi: 10.1007/s12311-024-01676-z
pii: 10.1007/s12311-024-01676-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Univerzita Karlova v Praze
ID : Cooperatio Program (research areas NEUR and MED/DIAG)
Organisme : Univerzita Karlova v Praze
ID : Cooperatio Program (research areas NEUR and MED/DIAG)
Organisme : Univerzita Karlova v Praze
ID : Cooperatio Program (research areas NEUR and MED/DIAG)
Organisme : Univerzita Karlova v Praze
ID : Cooperatio Program (research areas NEUR and MED/DIAG)
Organisme : Univerzita Karlova v Praze
ID : Cooperatio Program (research areas NEUR and MED/DIAG)
Organisme : Univerzita Karlova v Praze
ID : Cooperatio Program (research areas NEUR and MED/DIAG)
Organisme : Univerzita Karlova v Praze
ID : Cooperatio Program (research areas NEUR and MED/DIAG)
Organisme : Ministry of Education, Youth and Sports of the Czech Republic
ID : CZ.02.1.01/0.0/0.0/16_019/0000787 "Fighting INfectious Diseases"
Organisme : Ministry of Education, Youth and Sports of the Czech Republic
ID : CZ.02.1.01/0.0/0.0/16_019/0000787 "Fighting INfectious Diseases"
Organisme : European Union - Next Generation EU
ID : LX22NPO5107 (MEYS)
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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