Discovery of TRPA1 Antagonist
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
03 Mar 2024
03 Mar 2024
Historique:
medline:
3
3
2024
pubmed:
3
3
2024
entrez:
3
3
2024
Statut:
aheadofprint
Résumé
Transient receptor potential ankyrin 1 (TRPA1) is a nonselective calcium ion channel highly expressed in the primary sensory neurons, functioning as a polymodal sensor for exogenous and endogenous stimuli, and has been implicated in neuropathic pain and respiratory disease. Herein, we describe the optimization of potent, selective, and orally bioavailable TRPA1 small molecule antagonists with strong
Identifiants
pubmed: 38431835
doi: 10.1021/acs.jmedchem.3c02121
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM