Two-year neurodevelopmental outcome in extremely preterm-born children: The Austrian Preterm Outcome Study Group.
extremely preterm infants
neurodevelopmental impairment
risk predictors
Journal
Acta paediatrica (Oslo, Norway : 1992)
ISSN: 1651-2227
Titre abrégé: Acta Paediatr
Pays: Norway
ID NLM: 9205968
Informations de publication
Date de publication:
03 Mar 2024
03 Mar 2024
Historique:
revised:
24
01
2024
received:
15
11
2023
accepted:
22
02
2024
medline:
4
3
2024
pubmed:
4
3
2024
entrez:
3
3
2024
Statut:
aheadofprint
Résumé
The current study determined the neurodevelopmental outcome of extremely preterm infants at 2 years of age. All live-born infants 23-27 weeks of gestation born between 2011 and 2020 in Austria were included in a prospective registry. Neurodevelopmental outcome at 2 years of corrected age was assessed using Bayley Scales of Infant Development for both motor and cognitive scores, along with a neurological examination and an assessment of neurosensory function. 2378 out of 2905 (81.9%) live-born infants survived to 2 years of corrected age. Follow-up data were available for 1488 children (62.6%). Overall, 43.0% had no, 35.0% mild and 22.0% moderate-to-severe impairment. The percentage of children with moderate-to-severe neurodevelopmental impairment decreased with increasing gestational age and was 31.4%, 30.5%, 23.3%, 19.0% and 16.5% at 23, 24, 25, 26 and 27 weeks gestational age (p < 0.001). Results did not change over the 10-year period. In multivariate analysis, neonatal complications as well as male sex were significantly associated with an increased risk of neurodevelopmental impairment. In this cohort study, a 22.0% rate of moderate-to-severe neurodevelopmental impairment was observed among children born extremely preterm. This national data is important for both counselling parents and guiding the allocation of health resources.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Gemeinsame Gesundheitsziele aus dem Rahmen Pharmavertrag" of the "Main Association of the Austrian Social Insurance Carriers
Investigateurs
Herbert Kurz
(H)
Günther Bernert
(G)
Roland Berger
(R)
Angela Zacharasiewicz
(A)
Thomas Eiwegger
(T)
Doris Ehringer-Schetitska
(D)
Hans Salzer
(H)
Milana Unterweger-Jocic
(M)
Daniela Hofer
(D)
Hans Peter Wagentristl
(HP)
Klaus Abraham
(K)
Robert Birnbacher
(R)
Jörg Jahnel
(J)
Reinhold Kerbl
(R)
Christoph Seelbach
(C)
Martin Wald
(M)
Informations de copyright
© 2024 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.
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