The single nucleotide polymorphism rs4986790 (c.896A>G) in the gene

Background and aims

Several factors, such as hypertension and diabetes mellitus, are known to influence the course of coronavirus disease 2019 (COVID-19). However, there is currently little information on genetic markers that influence the severity of COVID-19. In this study, we specifically investigated the single nucleotide polymorphism (SNP) rs4986790 in the

Methods

We analyzed the influence of demographics, pre-existing conditions, inflammatory parameters at the time of hospitalization, and

Results

We confirmed that younger patient age and absence of pre-existing conditions were protective factors against disease progression. Furthermore, when comparing patients with mild SARS-CoV-2 infection with patients who required hospitalization or intensive care or even died due to COVID-19, the AG/GG genotype of

Conclusion

In this study, we identified an additional genetic factor that may serve as an invariant predictor of COVID-19 outcome. The

Informations de copyright

Copyright © 2024 Zacher, Schönfelder, Rohn, Siffert and Möhlendick.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.