Hydraulic conductivity of human cancer tissue: A hybrid study.
chemical engineering‐based bioprocessing
computational modeling
drug delivery
tissue engineering
Journal
Bioengineering & translational medicine
ISSN: 2380-6761
Titre abrégé: Bioeng Transl Med
Pays: United States
ID NLM: 101689146
Informations de publication
Date de publication:
Mar 2024
Mar 2024
Historique:
received:
06
06
2023
revised:
22
09
2023
accepted:
15
10
2023
medline:
4
3
2024
pubmed:
4
3
2024
entrez:
4
3
2024
Statut:
epublish
Résumé
Elevated tumor tissue interstitial fluid pressure (IFP) is an adverse biomechanical biomarker that predicts poor therapy response and an aggressive phenotype. Advances in functional imaging have opened the prospect of measuring IFP non-invasively. Image-based estimation of the IFP requires knowledge of the tissue hydraulic conductivity ( We measured the hydraulic conductivity of tumor tissue using modified Ussing chambers in surgical resection specimens. The effect of the tumor microenvironment (TME) on The results show that the hydraulic conductivity of human tumor tissues is very limited, ranging from approximately 10 Human tumor tissue is characterized by a very limited hydraulic conductivity, representing a barrier to effective drug transport. The results of this study can inform the development of realistic computational models, facilitate non-invasive IFP estimation, and contribute to stromal targeting anticancer therapies.
Sections du résumé
Background
UNASSIGNED
Elevated tumor tissue interstitial fluid pressure (IFP) is an adverse biomechanical biomarker that predicts poor therapy response and an aggressive phenotype. Advances in functional imaging have opened the prospect of measuring IFP non-invasively. Image-based estimation of the IFP requires knowledge of the tissue hydraulic conductivity (
Methods
UNASSIGNED
We measured the hydraulic conductivity of tumor tissue using modified Ussing chambers in surgical resection specimens. The effect of the tumor microenvironment (TME) on
Results
UNASSIGNED
The results show that the hydraulic conductivity of human tumor tissues is very limited, ranging from approximately 10
Conclusions
UNASSIGNED
Human tumor tissue is characterized by a very limited hydraulic conductivity, representing a barrier to effective drug transport. The results of this study can inform the development of realistic computational models, facilitate non-invasive IFP estimation, and contribute to stromal targeting anticancer therapies.
Identifiants
pubmed: 38435818
doi: 10.1002/btm2.10617
pii: BTM210617
pmc: PMC10905546
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e10617Informations de copyright
© 2023 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests relating to this work.