3α-Hydroxybufadienolides in Bufo gallbladders: structural insights and biotransformation.
Bufo gargarizans
Biotransformation
Bufadienolides
Self-defense
Toad bile
Journal
Natural products and bioprospecting
ISSN: 2192-2195
Titre abrégé: Nat Prod Bioprospect
Pays: Germany
ID NLM: 101577734
Informations de publication
Date de publication:
04 Mar 2024
04 Mar 2024
Historique:
received:
01
12
2023
accepted:
20
02
2024
medline:
4
3
2024
pubmed:
4
3
2024
entrez:
4
3
2024
Statut:
epublish
Résumé
Bufadienolides, naturally occurring steroids primarily found in toads, have garnered attention for their pharmacological properties and ecological significance. In this study, we isolated and identified 21 bufadienolides from the gallbladders of Bufo gargarizans, comprising four new compounds and 17 known ones. Notably, the predominance of 15 bufadienolides with a 3α-OH configuration in toad bile differs significantly from the 3β-OH bufadienolides found in venom secreted by toad glands. Moreover, our investigation into the biotransformation of 3β-OH and 3α-OH bufadienolides in the liver and kidney tissues of toads revealed an irreversible conversion from 3β-OH to 3α-OH bufadienolides, suggesting a crucial role in toad self-detoxification. These findings provide valuable insights into the structural diversity of bufadienolides and advance our understanding of their medical and ecological significance.
Identifiants
pubmed: 38436763
doi: 10.1007/s13659-024-00442-2
pii: 10.1007/s13659-024-00442-2
doi:
Types de publication
Journal Article
Langues
eng
Pagination
19Subventions
Organisme : Natural Science Foundation of Guangxi Province
ID : 2021GXNSFBA220068
Organisme : National Natural Science Foundation of China
ID : 81872760
Organisme : National Natural Science Foundation of China
ID : 82204975
Organisme : Natural Science Foundation of Guangdong Province
ID : 2021A1515011251
Organisme : Guangdong scientific scheme
ID : 2021A0505030032
Informations de copyright
© 2024. The Author(s).
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