Acute and short-term fluctuations in gravity are associated with changes in circulatory plasma protein levels.
Journal
NPJ microgravity
ISSN: 2373-8065
Titre abrégé: NPJ Microgravity
Pays: United States
ID NLM: 101703605
Informations de publication
Date de publication:
04 Mar 2024
04 Mar 2024
Historique:
received:
06
10
2023
accepted:
15
02
2024
medline:
5
3
2024
pubmed:
5
3
2024
entrez:
4
3
2024
Statut:
epublish
Résumé
Gravitational changes between micro- and hypergravity cause several adaptations and alterations in the human body. Besides muscular atrophy and immune system impairment, effects on the circulatory system have been described, which can be associated with a wide range of blood biomarker changes. This study examined nine individuals (seven males, two females) during a parabolic flight campaign (PFC). Thirty-one parabolas were performed in one flight day, resulting in ~22 s of microgravity during each parabola. Each participant was subjected to a single flight day with a total of 31 parabolas, totaling 11 min of microgravity during one parabolic flight. Before and after (1 hour (h) and 24 h), the flights blood was sampled to examine potential gravity-induced changes of circulating plasma proteins. Proximity Extension Assay (PEA) offers a proteomic solution, enabling the simultaneous analysis of a wide variety of plasma proteins. From 2925 unique proteins analyzed, 251 (8.58%) proteins demonstrated a differential regulation between baseline, 1 h and 24 h post flight. Pathway analysis indicated that parabolic flights led to altered levels of proteins associated with vesicle organization and apoptosis up to 24 h post microgravity exposure. Varying gravity conditions are associated with poorly understood physiological changes, including stress responses and fluid shifts. We provide a publicly available library of gravity-modulated circulating protein levels illustrating numerous changes in cellular pathways relevant for inter-organ function and communication.
Identifiants
pubmed: 38438462
doi: 10.1038/s41526-024-00370-y
pii: 10.1038/s41526-024-00370-y
doi:
Types de publication
Journal Article
Langues
eng
Pagination
25Subventions
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : 236177352- CRC1116
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : 236177352- CRC1116
Informations de copyright
© 2024. The Author(s).
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