The Association of Prenatal Diagnoses with Mortality and Long-Term Morbidity in Children with Specific Isolated Congenital Anomalies: A European Register-Based Cohort Study.
Congenital diaphragmatic hernia
Gastroschisis
Prenatal diagnosis
Spina bifida
Transposition of great arteries
Journal
Maternal and child health journal
ISSN: 1573-6628
Titre abrégé: Matern Child Health J
Pays: United States
ID NLM: 9715672
Informations de publication
Date de publication:
04 Mar 2024
04 Mar 2024
Historique:
accepted:
20
12
2023
medline:
5
3
2024
pubmed:
5
3
2024
entrez:
4
3
2024
Statut:
aheadofprint
Résumé
To compare 5-year survival rate and morbidity in children with spina bifida, transposition of great arteries (TGA), congenital diaphragmatic hernia (CDH) or gastroschisis diagnosed prenatally with those diagnosed postnatally. Population-based registers' data were linked to hospital and mortality databases. Children whose anomaly was diagnosed prenatally (n = 1088) had a lower mean gestational age than those diagnosed postnatally (n = 1698) ranging from 8 days for CDH to 4 days for TGA. Children with CDH had the highest infant mortality rate with a significant difference (p < 0.001) between those prenatally (359/1,000 births) and postnatally (116/1,000) diagnosed. For all four anomalies, the median length of hospital stay was significantly greater in children with a prenatal diagnosis than those postnatally diagnosed. Children with prenatally diagnosed spina bifida (79% vs 60%; p = 0.002) were more likely to have surgery in the first week of life, with an indication that this also occurred in children with CDH (79% vs 69%; p = 0.06). Our findings do not show improved outcomes for prenatally diagnosed infants. For conditions where prenatal diagnoses were associated with greater mortality and morbidity, the findings might be attributed to increased detection of more severe anomalies. The increased mortality and morbidity in those diagnosed prenatally may be related to the lower mean gestational age (GA) at birth, leading to insufficient surfactant for respiratory effort. This is especially important for these four groups of children as they have to undergo anaesthesia and surgery shortly after birth. Appropriate prenatal counselling about the time and mode of delivery is needed.
Identifiants
pubmed: 38438690
doi: 10.1007/s10995-024-03911-9
pii: 10.1007/s10995-024-03911-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Union's Horizon 2020 research and innovation programme
ID : 733001
Informations de copyright
© 2024. The Author(s).
Références
Adzick, N. S., Thom, E., Spong, C., et al. (2011). A randomized trial of prenatal versus postnatal repair of myelomeningocele. New England Journal of Medicine, 364(11), 993–1004. https://doi.org/10.1056/NEJMoa1014379
doi: 10.1056/NEJMoa1014379
Barriere, F., Michel, F., Loundou, A. D., et al. (2018). One-year outcome for congenital diaphragmatic hernia: Results from the french national register. Journal of Pediatrics, 02(193), 204–210.
doi: 10.1016/j.jpeds.2017.09.074
Bétrémieux, P., Gaillot, T., de la Pintière, A., et al. (2004). Congenital diaphragmatic hernia: Prenatal diagnosis permits immediate intensive care with high survival rate in isolated cases. A population-based study. Prenatal Diagnosis, 24(7), 487–493.
doi: 10.1002/pd.909
Bonnet, D., Coltri, A., Butera, G., et al. (1999). Detection of transposition of the great arteries in fetuses reduces neonatal morbidity and mortality. Circulation, 99(7), 916–918.
doi: 10.1161/01.CIR.99.7.916
Calderon, J., Angeard, N., Moutier, S., et al. (2012). Impact of prenatal diagnosis on neurocognitive outcomes in children with transposition of the great arteries. Journal of Pediatrics, 161(1), 94–8.e1.
doi: 10.1016/j.jpeds.2011.12.036
Cloete, E., Bloomfield, F. H., Sadler, L., et al. (2019). Antenatal detection of treatable critical congenital heart disease is associated with lower morbidity and mortality. Journal of Pediatrics, 204, 66–70.
doi: 10.1016/j.jpeds.2018.08.056
Colvin, J., Bower, C., Dickinson, J. E., & Sokol, J. (2005). Outcomes of congenital diaphragmatic hernia: A population-based study in Western Australia. Pediatrics, 116(3), e356–e363.
doi: 10.1542/peds.2004-2845
Costello, J. M., Pasquali, S. K., Jacobs, J. P., et al. (2014). Gestational age at birth and outcomes after neonatal cardiac surgery: An analysis of the society of thoracic surgeons congenital heart surgery database. Circulation, 129(24), 2511–2517. https://doi.org/10.1161/CIRCULATIONAHA.113.005864
doi: 10.1161/CIRCULATIONAHA.113.005864
D’Antonio, F., Virgone, C., Rizzo, G., et al. (2015). Prenatal risk factors and outcomes in gastroschisis: A meta-analysis. Pediatrics, 136(1), e159–e169.
doi: 10.1542/peds.2015-0017
Deprest, J. A., Benachi, A., Gratacos, E., Nicolaides, K. H., Berg, C., Persico, N., Belfort, M., Gardener, G. J., Ville, Y., Johnson, A., Morini, F., Wielgoś, M., Van Calster, B., DeKoninck, P. L. J., TOTAL Trial for Moderate Hypoplasia Investigators. (2021). Randomized Trial of fetal surgery for moderate left diaphragmatic hernia. New England Journal of Medicine, 385(2), 119–129. https://doi.org/10.1056/NEJMoa2026983
doi: 10.1056/NEJMoa2026983
Deprest, J. A., Nicolaides, K. H., Benachi, A., Gratacos, E., Ryan, G., Persico, N., Sago, H., Johnson, A., Wielgoś, M., Berg, C., Van Calster, B., Russo, F. M., TOTAL Trial for Severe Hypoplasia Investigators. (2021). Randomized trial of fetal surgery for severe left diaphragmatic hernia. New England Journal of Medicine, 385(2), 107–118. https://doi.org/10.1056/NEJMoa2027030
doi: 10.1056/NEJMoa2027030
Domínguez-Manzano, P., Herraiz, I., Mendoza, A., et al. (2017). Impact of prenatal diagnosis of transposition of the great arteries on postnatal outcome. The Journal of Maternal-Fetal & Neonatal Medicine, 30(23), 2858–2863.
doi: 10.1080/14767058.2016.1265934
Douglas Wilson, R., Van Mieghem, T., Langlois, S., & Church, P. (2021). Guideline No. 410: Prevention, Screening, diagnosis, and pregnancy management for fetal neural tube defects. Journal of Obstetrics and Gynaecology Canada, 43(1), 124-139 e8. https://doi.org/10.1016/j.jogc.2020.11.003 . Epub 2020 Nov 17 PMID: 33212246.
doi: 10.1016/j.jogc.2020.11.003
Gamba, P., & Midrio, P. (2014). Abdominal wall defects: Prenatal diagnosis, newborn management, and long-term outcomes. Seminars in Pediatric Surgery, 23(5), 283–290. https://doi.org/10.1053/j.sempedsurg.2014.09.009
doi: 10.1053/j.sempedsurg.2014.09.009
Garne, E., Dolk, H., Loane, M., et al. (2011). Paper 5: Surveillance of multiple congenital anomalies: Implementation of a computer algorithm in European registers for classification of cases. Birth Defects Research (part a), 91, S44–S50. https://doi.org/10.1002/bdra.20777
doi: 10.1002/bdra.20777
Glinianaia, S., Rankin, J., Pierini, A., et al. (2022). Ten-year survival of children with congenital anomalies: A European cohort study. Pediatrics, 149(3), e2021053793.
doi: 10.1542/peds.2021-053793
Goldstein, M. J., Bailer, J. M., & Gonzalez-Brown, V. M. (2022). Preterm vs term delivery in antenatally diagnosed gastroschisis: A systematic review and meta-analysis. American Journal of Obstetrics & Gynecology MFM, 4(4), 100651. https://doi.org/10.1016/j.ajogmf.2022.100651
doi: 10.1016/j.ajogmf.2022.100651
Grivell, R. M., Andersen, C., & Dodd, J. M. (2014). Prenatal versus postnatal repair procedures for spina bifida for improving infant and maternal outcomes. Cochrane Database of Systematic Reviews, 28(10), CD008825. https://doi.org/10.1002/14651858.CD008825.pub2
doi: 10.1002/14651858.CD008825.pub2
Ho, P., Quigley, M. A., Tatwavedi, D., Britto, C., & Kurinczuk, J. J. (2021). Neonatal and infant mortality associated with spina bifida: A systematic review and meta-analysis. PloS one, 16(5), e0250098. https://doi.org/10.1371/journal.pone.0250098
doi: 10.1371/journal.pone.0250098
Jordan, S., Emery, S., Watkins, A., et al. (2009). Associations of drugs routinely given in labour with breastfeeding at 48 hours: Analysis of the Cardiff Births Survey. BJOG, 116(12), 1622–1629.
doi: 10.1111/j.1471-0528.2009.02256.x
Kunde, F., Thomas, S., Sudhakar, A., et al. (2021). Prenatal diagnosis and planned peripartum care improve perinatal outcome of fetuses with transposition of the great arteries and intact ventricular septum in low-resource settings. Ultrasound in Obstetrics and Gynecology, 58(3), 398–404.
doi: 10.1002/uog.23146
Lazar, D. A., Cass, D. L., Rodriguez, M. A., et al. (2011). Impact of prenatal evaluation and protocol based perinatal management on congenital diaphragmatic hernia outcomes. Journal of Pediatric Surgery, 46(5), 808–813. https://doi.org/10.1016/j.jpedsurg.2011.02.009
doi: 10.1016/j.jpedsurg.2011.02.009
Lewis, D., Tolosa, J. E., Kaufmann, M., et al. (2004). Elective cesarean delivery and long-term motor function or ambulation status in infants with meningomyelocele. Obstetrics and Gynecology, 103(3), 469–473. https://doi.org/10.1097/01.AOG.0000113624.94710.ce
doi: 10.1097/01.AOG.0000113624.94710.ce
Loane, M., Given, J. E., Tan, J., et al. (2021). Linking a European cohort of children born with congenital anomalies to vital statistics and mortality records: A EUROlinkCAT study. PloS one, 16(8), e0256535. https://doi.org/10.1371/journal.pone.0256535
doi: 10.1371/journal.pone.0256535
Loane, M., Given, J. E., Tan, J., et al. (2023). Creating a population-based cohort of children born with and without congenital anomalies using birth data matched to hospital discharge databases in 11 European regions: Assessment of linkage success and data quality. PloS one, 18(8), e0290711. https://doi.org/10.1371/journal.pone.0290711
doi: 10.1371/journal.pone.0290711
Long, A.-M., Bunch, K. J., Knight, M., et al. (2019). One-year outcomes of infants born with congenital diaphragmatic hernia: A national population cohort study. Archives of Disease in Childhood. Fetal and Neonatal Edition, 104, F643–F647. https://doi.org/10.1136/archdischild-2018-316396
doi: 10.1136/archdischild-2018-316396
Mesas Burgos, C., Hammarqvist-Vejde, J., Frenckner, B., & Conner, P. (2016). Differences in outcomes in prenatally diagnosed congenital diaphragmatic hernia compared to postnatal detection: A single-center experience. Fetal Diagnosis and Therapy, 39(4), 241–247. https://doi.org/10.1159/000439303
doi: 10.1159/000439303
Nagata, H., Glick, L., Lougheed, J., et al. (2020). Prenatal diagnosis of transposition of the great arteries reduces postnatal mortality: a population-based study. Canadian Journal of Cardiology, 36(10), 1592–1597.
doi: 10.1016/j.cjca.2020.01.010
Peake, L. K., Draper, E. S., Budd, J. L., & Field, D. (2015). Outcomes when congenital heart disease is diagnosed antenatally versus postnatally in the UK: A retrospective population-based study. BMC Pediatrics, 15, 58.
doi: 10.1186/s12887-015-0370-3
Peyvandi, S., De Santiago, V., Chakkarapani, E., Chau, V., et al. (2016). Association of prenatal diagnosis of critical congenital heart disease with postnatal brain development and the risk of brain injury. JAMA Pediatrics, 170(4), e154450. https://doi.org/10.1001/jamapediatrics.2015.4450
doi: 10.1001/jamapediatrics.2015.4450
Russo, F. M., Cordier, A. G., De Catte, L., et al. (2018). Workstream Prenatal Proposal for standardized prenatal ultrasound assessment of the fetus with congenital diaphragmatic hernia by the European reference network on rare inherited and congenital anomalies (ERNICA). Prenatal Diagnosis, 38(9), 629–637.
doi: 10.1002/pd.5297
Sadlecki, P., & Walentowicz-Sadlecka, M. (2023). Prenatal diagnosis of fetal defects and its implications on the delivery mode. Open Med (wars)., 18(1), 20230704. https://doi.org/10.1515/med-2023-0704
doi: 10.1515/med-2023-0704
Sipes, S. L., Weiner, C. P., Sipes, D. R., 2nd., et al. (1990). Gastroschisis and omphalocele: Does either antenatal diagnosis or route of delivery make a difference in perinatal outcome? Obstetrics and Gynecology, 76(2), 195–199.
Skari, H., Bjornland, K., Bjornstad-Ostensen, A., et al. (1998). Consequences of prenatal ultrasound diagnosis: A preliminary report on neonates with congenital malformations. Acta Obstetricia Et Gynecologica Scandinavica, 77(6), 635–642.
doi: 10.1034/j.1600-0412.1998.770610.x
Urhoj, S. K., Tan, J., Morris, J. K., et al. (2022). Hospital length of stay among children with and without congenital anomalies across 11 European regions—A population-based data linkage study. PloS one, 17(7), e0269874. https://doi.org/10.1371/journal.pone.0269874
doi: 10.1371/journal.pone.0269874
van Velzen, C. L., Haak, M. C., Reijnders, G., et al. (2015). Prenatal detection of transposition of the great arteries reduces mortality and morbidity. Ultrasound in Obstetrics and Gynecology, 45(3), 320–325.
doi: 10.1002/uog.14689