Epigenetic aging of human blood cells is influenced by the age of the host body.
aging
epigenetic
hematopoietic
hsc
human
parabiosis
transplantation
Journal
Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839
Informations de publication
Date de publication:
04 Mar 2024
04 Mar 2024
Historique:
revised:
05
12
2023
received:
23
08
2023
accepted:
30
01
2024
medline:
5
3
2024
pubmed:
5
3
2024
entrez:
5
3
2024
Statut:
aheadofprint
Résumé
Allogenic hematopoietic stem cell transplantation is a therapeutic procedure performed over a wide range of donor and recipient age combinations, representing natural experiments of how the age of the recipient affects aging in transplanted donor cells in vivo. We measured DNA methylation and epigenetic aging in donors and recipients and found that biological epigenetic clocks are accelerated in cells transplanted into an older body and decelerated in a younger body. This is the first evidence that the age of the circulating environment influences human epigenetic aging in vivo.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14112Subventions
Organisme : Helse Sør-Øst RHF
Organisme : Kreftforeningen
Organisme : Norges Forskningsråd
Informations de copyright
© 2024 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.
Références
Belsky, D. W., Caspi, A., Arseneault, L., Baccarelli, A., Corcoran, D., Gao, X., Hannon, E., Harrington, H. L., Rasmussen, L. J. H., Houts, R., Huffman, K., Kraus, W. E., Kwon, D., Mill, J., Pieper, C. F., Prinz, J., Poulton, R., Schwartz, J., Sugden, K., … Moffitt, T. E. (2020). Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm. eLife, 9, 1-56. https://doi.org/10.7554/eLife.54870
Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weismann, I. L., & Rando, T. A. (2005). Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature, 433(7027), 760-764. https://doi.org/10.1038/nature03260
Hannum, G., Guinney, J., Zhao, L., Zhang, L., Hughes, G., Sadda, S. V., Klotzle, B., Bibikova, M., Fan, J. B., Gao, Y., Deconde, R., Chen, M., Rajapakse, I., Friend, S., Ideker, T., & Zhang, K. (2013). Genome-wide methylation profiles reveal quantitative views of human aging rates. Molecular Cell, 49(2), 359-367. https://doi.org/10.1016/j.molcel.2012.10.016
Higgins-Chen, A. T., Thrush, K. L., Wang, Y., Minteer, C. J., Kuo, P.-L., Wang, M., Niimi, P., Sturm, G., Lin, J., Moore, A. Z., Bandinelli, S., Vinkers, C. H., Vermetten, E., Rutten, B. P. F., Geuze, E., Okhuijsen-Pfeifer, C., van der Horst, M. Z., Schreiter, S., Gutwinski, S., … Levine, M. E. (2022). A computational solution for bolstering reliability of epigenetic clocks: Implications for clinical trials and longitudinal tracking. Nature Aging, 2(7), 644-661. https://doi.org/10.1038/s43587-022-00248-2
Horvath, S. (2013). DNA methylation age of human tissues and cell types. Genome Biology, 14, R115.
Horvath, S., Oshima, J., Martin, G. M., Lu, A. T., Quach, A., Cohen, H., Felton, S., Matsuyama, M., Lowe, D., Kabacik, S., Wilson, J. G., Reiner, A. P., Maierhofer, A., Flunkert, J., Aviv, A., Hou, L., Baccarelli, A. A., Li, Y., Stewart, J. D., … Raj, K. (2018). Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies. Aging, 10(7), 1758-1775. https://doi.org/10.18632/aging.101508
Lee, J. J., Kook, H., Chung, I. J., Kim, H. J., Park, M. R., Kim, C. J., Nah, J. A., & Hwang, T. J. (1999). Telomere length changes in patients undergoing hematopoietic stem cell transplantation. Bone Marrow Transplantation, 24(4), 411-415. https://doi.org/10.1038/sj.bmt.1701923
Levine, M. E., Lu, A. T., Quach, A., Chen, B. H., Assimes, T. L., Bandinelli, S., Hou, L., Baccarelli, A. A., Stewart, J. D., Li, Y., Whitsel, E. A., Wilson, J. G., Reiner, A. P., Aviv, A., Lohman, K., Liu, Y., Ferrucci, L., & Horvath, S. (2018). An epigenetic biomarker of aging for lifespan and healthspan. Aging, 10(4), 573-591. https://doi.org/10.18632/aging.101414
Lu, A. T., Binder, A. M., Zhang, J., Yan, Q., Reiner, A. P., Cox, S. R., Corley, J., Harris, S. E., Kuo, P.-L., Moore, A. Z., Bandinelli, S., Stewart, J. D., Wang, C., Hamlat, E. J., Epel, E. S., Schwartz, J. D., Whitsel, E. A., Correa, A., Ferrucci, L., … Horvath, S. (2022). DNA methylation GrimAge version 2. Aging, 14(23), 9484-9549. https://doi.org/10.18632/aging.204434
Lu, A. T., Quach, A., Wilson, J. G., Reiner, A. P., Aviv, A., Raj, K., Hou, L., Baccarelli, A. A., Li, Y., Stewart, J. D., Whitsel, E. A., Assimes, T. L., Ferrucci, L., & Horvath, S. (2019). DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging, 11(2), 303-327. https://doi.org/10.18632/aging.101684
Lu, A. T., Seeboth, A., Tsai, P. C., Sun, D., Quach, A., Reiner, A. P., Kooperberg, C., Ferrucci, L., Hou, L., Baccarelli, A. A., Li, Y., Harris, S. E., Corley, J., Taylor, A., Deary, I. J., Stewart, J. D., Whitsel, E. A., Assimes, T. L., Chen, W., … Horvath, S. (2019). DNA methylation-based estimator of telomere length. Aging, 11(16), 5895-5923. https://doi.org/10.18632/aging.102173
Ma, S., Wang, S., Ye, Y., Ren, J., Chen, R., Li, W., Li, J., Zhao, L., Zhao, Q., Sun, G., Jing, Y., Zuo, Y., Xiong, M., Yang, Y., Wang, Q., Lei, J., Sun, S., Long, X., Song, M., … Liu, G.-H. (2022). Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues. Cell Stem Cell, 29(6), 990-1005.e10. https://doi.org/10.1016/j.stem.2022.04.017
Poganik, J. R., Zhang, B., Baht, G. S., Tyshkovskiy, A., Deik, A., Kerepesi, C., Yim, S. H., Lu, A. T., Haghani, A., Gong, T., Hedman, A. M., Andolf, E., Pershagen, G., Almqvist, C., Clish, C. B., Horvath, S., White, J. P., & Gladyshev, V. N. (2023). Biological age is increased by stress and restored upon recovery. Cell Metabolism, 35(5), 807-820.e5. https://doi.org/10.1016/j.cmet.2023.03.015
Shaw, B. E., Logan, B. R., Spellman, S. R., Marsh, S. G. E., Robinson, J., Pidala, J., Hurley, C., Barker, J., Maiers, M., Dehn, J., Wang, H., Haagenson, M., Porter, D., Petersdorf, E. W., Woolfrey, A., Horowitz, M. M., Verneris, M., Hsu, K. C., Fleischhauer, K., & Lee, S. J. (2018). Development of an unrelated donor selection score predictive of survival after HCT: Donor age matters most. Biology of Blood and Marrow Transplantation, 24(5), 1049-1056. https://doi.org/10.1016/j.bbmt.2018.02.006
Søraas, A., Matsuyama, M., de Lima, M., Wald, D., Buechner, J., Gedde-Dahl, T., Søraas, C. L., Chen, B., Ferrucci, L., Dahl, J. A., Horvath, S., & Matsuyama, S. (2019). Epigenetic age is a cell-intrinsic property in transplanted human hematopoietic cells. Aging Cell, 18(2), e12897. https://doi.org/10.1111/acel.12897
Stölzel, F., Brosch, M., Horvath, S., Kramer, M., Thiede, C., Von Bonin, M., Ammerpohl, O., Middeke, M., Schetelig, J., Ehninger, G., Hampe, J., & Bornhäuser, M. (2017). Dynamics of epigenetic age following hematopoietic stem cell transplantation. Haematologica, 102(8), e321-e323. https://doi.org/10.3324/HAEMATOL.2016.160481
Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., Lucin, K. M., Czirr, E., Park, J. S., Couillard-Després, S., Aigner, L., Li, G., Peskind, E. R., Kaye, J. A., Quinn, J. F., … Wyss-Coray, T. (2011). The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature, 477(7362), 90-96. https://doi.org/10.1038/nature10357
Zhang, B., Lee, D. E., Trapp, A., Tyshkovskiy, A., Lu, A. T., Bareja, A., Kerepesi, C., McKay, L. K., Shindyapina, A. V., Dmitriev, S. E., Baht, G. S., Horvath, S., Gladyshev, V. N., & White, J. P. (2023). Multi-omic rejuvenation and life span extension on exposure to youthful circulation. Nature Aging, 3, 948-964. https://doi.org/10.1038/s43587-023-00451-9