CD4

CD4(+) T helper 1 cells T cell trafficking checkpoint blockade head and neck squamous cell carcinoma immunotherapy mechanisms of response peripheral blood mononuclear cells single-cell omics tumor microenvironment tumor-draining lymph node

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
01 Mar 2024
Historique:
received: 26 12 2022
revised: 30 11 2023
accepted: 08 02 2024
pubmed: 6 3 2024
medline: 6 3 2024
entrez: 5 3 2024
Statut: aheadofprint

Résumé

Cancer patients often receive a combination of antibodies targeting programmed death-ligand 1 (PD-L1) and cytotoxic T lymphocyte antigen-4 (CTLA4). We conducted a window-of-opportunity study in head and neck squamous cell carcinoma (HNSCC) to examine the contribution of anti-CTLA4 to anti-PD-L1 therapy. Single-cell profiling of on- versus pre-treatment biopsies identified T cell expansion as an early response marker. In tumors, anti-PD-L1 triggered the expansion of mostly CD8

Identifiants

DOI: 10.1016/j.immuni.2024.02.007 PMID: 38442708
pubmed: 38442708
pii: S1074-7613(24)00083-9
doi: 10.1016/j.immuni.2024.02.007
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests P.M.C. reports the mentioned grant and non-financial support from AstraZeneca during the study; personal fees and non-financial support from AbbVie, Bayer, Bristol-Myers Squibb, Merck, LEO Pharma, and Vifor Pharma; personal fees from Daiichii Sankyo, and Rakuten; and non-financial support from Teva, Novartis, Amgen, and Roche outside the submitted work.

Auteurs

Amelie Franken (A)

Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium; VIB Center for Cancer Biology, Leuven 3000, Belgium.

Michel Bila (M)

Laboratory of Experimental Oncology (LEO), Department of Oncology, KU Leuven, 3000 Leuven, Belgium; Department of General Medical Oncology, UZ Leuven, 3000 Leuven, Belgium; Department of Oral and Maxillofacial Surgery, UZ Leuven, Leuven 3000, Belgium.

Aurelie Mechels (A)

Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium; VIB Center for Cancer Biology, Leuven 3000, Belgium.

Sam Kint (S)

Laboratory of Reproductive Genomics, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium; KU Leuven Institute for Single Cell Omics (LISCO), Leuven 3000, Belgium.

Jeroen Van Dessel (J)

Department of Oral and Maxillofacial Surgery, UZ Leuven, Leuven 3000, Belgium.

Valentina Pomella (V)

Digestive Oncology, KU Leuven, UZ Leuven, Leuven 3000, Belgium.

Sebastiaan Vanuytven (S)

Laboratory of Reproductive Genomics, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium; KU Leuven Institute for Single Cell Omics (LISCO), Leuven 3000, Belgium.

Gino Philips (G)

Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium; VIB Center for Cancer Biology, Leuven 3000, Belgium.

Orian Bricard (O)

Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium; VIB Center for Cancer Biology, Leuven 3000, Belgium.

Jieyi Xiong (J)

Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium; VIB Center for Cancer Biology, Leuven 3000, Belgium.

Bram Boeckx (B)

Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium; VIB Center for Cancer Biology, Leuven 3000, Belgium.

Sigrid Hatse (S)

Laboratory of Experimental Oncology (LEO), Department of Oncology, KU Leuven, 3000 Leuven, Belgium; Department of General Medical Oncology, UZ Leuven, 3000 Leuven, Belgium.

Thomas Van Brussel (T)

Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium; VIB Center for Cancer Biology, Leuven 3000, Belgium.

Rogier Schepers (R)

Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium; VIB Center for Cancer Biology, Leuven 3000, Belgium.

Cedric Van Aerde (C)

Department of Imaging and Pathology, KU Leuven, UZ Leuven, Leuven 3000, Belgium.

Sarah Geurs (S)

Laboratory of Reproductive Genomics, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium; KU Leuven Institute for Single Cell Omics (LISCO), Leuven 3000, Belgium; Department of Biomolecular Medicine, UZ Ghent, Ghent 9052, Belgium.

Vincent Vandecaveye (V)

Otorhinolaryngology, Head and Neck Surgery, Leuven 3000, Belgium.

Esther Hauben (E)

Otorhinolaryngology, Head and Neck Surgery, Leuven 3000, Belgium.

Vincent Vander Poorten (V)

Otorhinolaryngology, Head and Neck Surgery, Leuven 3000, Belgium; Department of Oncology, Section Head and Neck Oncology, Leuven 3000, Belgium.

Sara Verbandt (S)

Digestive Oncology, KU Leuven, UZ Leuven, Leuven 3000, Belgium.

Katy Vandereyken (K)

Laboratory of Reproductive Genomics, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium; KU Leuven Institute for Single Cell Omics (LISCO), Leuven 3000, Belgium.

Junbin Qian (J)

Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; Institute of Genetics, Zhejiang University School of Medicine, Hangzhou 310058, China.

Sabine Tejpar (S)

Digestive Oncology, KU Leuven, UZ Leuven, Leuven 3000, Belgium.

Thierry Voet (T)

Laboratory of Reproductive Genomics, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium; KU Leuven Institute for Single Cell Omics (LISCO), Leuven 3000, Belgium.

Paul M Clement (PM)

Laboratory of Experimental Oncology (LEO), Department of Oncology, KU Leuven, 3000 Leuven, Belgium; Department of General Medical Oncology, UZ Leuven, 3000 Leuven, Belgium. Electronic address: paul.clement@uzleuven.be.

Diether Lambrechts (D)

Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium; VIB Center for Cancer Biology, Leuven 3000, Belgium; KU Leuven Institute for Single Cell Omics (LISCO), Leuven 3000, Belgium. Electronic address: diether.lambrechts@kuleuven.be.

Classifications MeSH