Altered structural and functional connectivity in Posterior Cortical Atrophy and Dementia with Lewy bodies.

Posterior cortical atrophy (PCA) and dementia with Lewy bodies (DLB) show distinct atrophy and overlapping hypometabolism profiles, but it is unknown how disruptions in structural and functional connectivity compare between these disorders and whether breakdowns in connectivity relate to either atrophy or hypometabolism. Thirty amyloid-positive PCA patients, 24 amyloid-negative DLB patients and 30 amyloid-negative cognitively unimpaired (CU) healthy individuals were recruited at Mayo Clinic, Rochester, MN, and underwent a 3T head MRI, including structural MRI, resting state functional MRI (rsfMRI) and diffusion tensor imaging (DTI) sequences, as well as [

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Déclaration de conflit d'intérêts

Declaration of competing interest Dr. Singh, Dr. Carlos, Dr. Sintini, Dr. Reid, Carling Robinson and Austin Goodrich have no disclosures to report. Dr. Whitwell, Dr. Machulda and Dr. Josephs reported receiving research funding from the NIH. Dr. Graff-Radford reported receiving research support from the NIH and he also serves as an editorial board member for Neurology. Dr. Jack receives no personal compensation from any commercial entity and has no conflicts. He receives research support from NIH, the GHR foundation and the Alexander Family Alzheimer's Disease Research Professorship of the Mayo Clinic. Dr. Lowe reported consulting for Bayer Schering Pharma, Piramal Life Sciences, Life Molecular Imaging, Eisai Inc., AVID Radiopharmaceuticals, and Merck Research and receiving research support from GE Healthcare, Siemens Molecular Imaging, AVID Radiopharmaceuticals, Elli Lilly and Company and the NIH (NIA, NCI). Dr. Peterson reported serving on scientific advisory boards for Elan Pharmaceuticals and GE Healthcare, he receives royalties from publishing mild cognitive impairment (Oxford University Press, 2003) and receives research support from NIH. Dr. Kantarci receives research support from the NIH (K23 AG030935 [PI], P50 AG16574/P1 [PI], and R01 AG11378 [Co-]). Dr. Boeve has served as a consultant to GE Healthcare; receives royalties from the publication of Behavioral Neurology of Dementia (Cambridge Medicine, 2009); and receives research support from Myriad Genetics Inc., Cephalon, Inc., the NIH (P50 AG16574 [Co-I], UO1 AG06786 [Co-I, and RO1 AG15866 [Co-I]), the Alzheimer's Association, and the Center for Inherited Disease Research (U24 AG026395 [Co-I]).