Specific pharmacological and G


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
05 Mar 2024
Historique:
received: 08 08 2022
accepted: 15 02 2024
medline: 6 3 2024
pubmed: 6 3 2024
entrez: 5 3 2024
Statut: epublish

Résumé

G protein-coupled receptors (GPCRs) constitute the largest family of membrane proteins and are important drug targets. The discovery of drugs targeting these receptors and their G protein signaling properties are based on assays mainly performed with modified receptors expressed in heterologous cells. However, GPCR responses may differ in their native environment. Here, by using highly sensitive G

Identifiants

pubmed: 38443355
doi: 10.1038/s41467-024-46177-z
pii: 10.1038/s41467-024-46177-z
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1990

Subventions

Organisme : Agence Nationale de la Recherche (French National Research Agency)
ID : 18-CE11-0004-01
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 32271198
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 2022YFA1302901
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 32330049
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 82320108021

Informations de copyright

© 2024. The Author(s).

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Auteurs

Chanjuan Xu (C)

Cellular Signaling Laboratory, Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Bioland Laboratory, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, 510005, Guangzhou, China.

Yiwei Zhou (Y)

Cellular Signaling Laboratory, Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Kindstar Global Precision Medicine Institute, Wuhan, China.

Yuxuan Liu (Y)

Cellular Signaling Laboratory, Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Li Lin (L)

Cellular Signaling Laboratory, Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Peng Liu (P)

Cellular Signaling Laboratory, Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Xiaomei Wang (X)

Cellular Signaling Laboratory, Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Zhengyuan Xu (Z)

Cellular Signaling Laboratory, Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Jean-Philippe Pin (JP)

Institut de Génomique Fonctionnelle (IGF), Université de Montpellier, CNRS, INSERM, 34094, Montpellier, France. jean-philippe.pin@igf.cnrs.fr.

Philippe Rondard (P)

Institut de Génomique Fonctionnelle (IGF), Université de Montpellier, CNRS, INSERM, 34094, Montpellier, France. philippe.rondard@igf.cnrs.fr.

Jianfeng Liu (J)

Cellular Signaling Laboratory, Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China. jfliu@mail.hust.edu.cn.
Bioland Laboratory, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, 510005, Guangzhou, China. jfliu@mail.hust.edu.cn.

Classifications MeSH