OPENPichia: licence-free Komagataella phaffii chassis strains and toolkit for protein expression.


Journal

Nature microbiology
ISSN: 2058-5276
Titre abrégé: Nat Microbiol
Pays: England
ID NLM: 101674869

Informations de publication

Date de publication:
Mar 2024
Historique:
received: 23 03 2023
accepted: 01 12 2023
medline: 6 3 2024
pubmed: 6 3 2024
entrez: 5 3 2024
Statut: ppublish

Résumé

The industrial yeast Komagataella phaffii (formerly named Pichia pastoris) is commonly used to synthesize recombinant proteins, many of which are used as human therapeutics or in food. However, the basic strain, named NRRL Y-11430, from which all commercial hosts are derived, is not available without restrictions on its use. Comparative genome sequencing leaves little doubt that NRRL Y-11430 is derived from a K. phaffii type strain deposited in the UC Davis Phaff Yeast Strain Collection in 1954. We analysed four equivalent type strains in several culture collections and identified the NCYC 2543 strain, from which we started to develop an open-access Pichia chassis strain that anyone can use to produce recombinant proteins to industry standards. NRRL Y-11430 is readily transformable, which we found to be due to a HOC1 open-reading-frame truncation that alters cell-wall mannan. We introduced the HOC1 open-reading-frame truncation into NCYC 2543, which increased the transformability and improved secretion of some but not all of our tested proteins. We provide our genome-sequenced type strain, the hoc1

Identifiants

pubmed: 38443579
doi: 10.1038/s41564-023-01574-w
pii: 10.1038/s41564-023-01574-w
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

864-876

Informations de copyright

© 2024. The Author(s).

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Auteurs

Katrien Claes (K)

Center for Medical Biotechnology, VIB, Ghent, Belgium. Katrien.Claes@vib-ugent.be.
Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium. Katrien.Claes@vib-ugent.be.

Dries Van Herpe (D)

Center for Medical Biotechnology, VIB, Ghent, Belgium.
Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.
Inbiose NV, Ghent, Belgium.

Robin Vanluchene (R)

Center for Medical Biotechnology, VIB, Ghent, Belgium.
Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.

Charlotte Roels (C)

Center for Medical Biotechnology, VIB, Ghent, Belgium.
Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.

Berre Van Moer (B)

Center for Medical Biotechnology, VIB, Ghent, Belgium.
Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.

Elise Wyseure (E)

Center for Medical Biotechnology, VIB, Ghent, Belgium.
Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.

Kristof Vandewalle (K)

Center for Medical Biotechnology, VIB, Ghent, Belgium.
Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.

Hannah Eeckhaut (H)

Center for Medical Biotechnology, VIB, Ghent, Belgium.
Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.

Semiramis Yilmaz (S)

Center for Medical Biotechnology, VIB, Ghent, Belgium.
Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.

Sandrine Vanmarcke (S)

Center for Medical Biotechnology, VIB, Ghent, Belgium.
Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.

Erhan Çıtak (E)

Center for Medical Biotechnology, VIB, Ghent, Belgium.
Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.

Daria Fijalkowska (D)

Center for Medical Biotechnology, VIB, Ghent, Belgium.
Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.

Hendrik Grootaert (H)

Center for Medical Biotechnology, VIB, Ghent, Belgium.
Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.

Chiara Lonigro (C)

Center for Medical Biotechnology, VIB, Ghent, Belgium.
Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.

Leander Meuris (L)

Center for Medical Biotechnology, VIB, Ghent, Belgium.
Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.

Gitte Michielsen (G)

Center for Medical Biotechnology, VIB, Ghent, Belgium.
Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.

Justine Naessens (J)

Center for Medical Biotechnology, VIB, Ghent, Belgium.
Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.

Loes van Schie (L)

Center for Medical Biotechnology, VIB, Ghent, Belgium.
Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.

Riet De Rycke (R)

Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
BioImaging Core, VIB, Ghent, Belgium.

Michiel De Bruyne (M)

Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
BioImaging Core, VIB, Ghent, Belgium.

Peter Borghgraef (P)

BioImaging Core, VIB, Ghent, Belgium.

Nico Callewaert (N)

Center for Medical Biotechnology, VIB, Ghent, Belgium. Nico.Callewaert@vib-ugent.be.
Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium. Nico.Callewaert@vib-ugent.be.

Classifications MeSH