Trans-Synaptic Degeneration in the Visual Pathway in Patients With Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
09 Apr 2024
Historique:
medline: 6 3 2024
pubmed: 6 3 2024
entrez: 6 3 2024
Statut: ppublish

Résumé

We aimed to assess the presence of retinal neurodegeneration independent of optic neuritis (ON) in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and to investigate the development of trans-synaptic anterograde degeneration in these patients after ON. Cross-sectional, retrospective study of 34 adult patients with MOGAD and 23 healthy controls (HC). Clinical, optical coherence tomography (OCT), and MRI data were collected. Peripapillary retinal nerve fiber layer (pRNFL) and ganglion cell inner plexiform layer (GCIPL) were obtained using Heidelberg Spectralis. FreeSurfer7 was used to obtain the lateral geniculate nucleus (LGN), occipital volume fractions (to total estimated intracranial volume), and occipital cortical thickness. For the anterior visual pathway, the analysis was conducted using eyes, classified based on the history of ON (Eye-ON and Eye-NON) and compared with Eye-HC. The analysis of OCT and brain volumetric measures was conducted comparing MOGAD-ON, MOGAD-NON, and HC groups. The analysis of covariance with a Bonferroni-adjusted post hoc test was used to test differences between groups and linear regression analysis to evaluate OCT/MRI associations; age and sex were considered as covariates. 24 (70.5%) patients had a prior ON. Median pRNFL and GCIPL thickness (um) was significantly reduced in Eye-ON vs EyeNON and HC (pRNFL: 69.4 (17.3), 89.6 (13.7), 98.2 (11.7), Compared with HC, MOGAD-ON exhibits reduced retinal thickness, primarily influenced by the presence and the number of prior ON episodes. Moreover, MOGAD-ON demonstrates significant atrophy in the retinal, subcortical, and cortical regions of the visual pathway, distinguishing them from MOGAD-NON and HC. These findings suggest that in patients with MOGAD neurodegeneration is tightly correlated with damage to the involved pathway.

Sections du résumé

BACKGROUND AND OBJECTIVES OBJECTIVE
We aimed to assess the presence of retinal neurodegeneration independent of optic neuritis (ON) in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and to investigate the development of trans-synaptic anterograde degeneration in these patients after ON.
METHODS METHODS
Cross-sectional, retrospective study of 34 adult patients with MOGAD and 23 healthy controls (HC). Clinical, optical coherence tomography (OCT), and MRI data were collected. Peripapillary retinal nerve fiber layer (pRNFL) and ganglion cell inner plexiform layer (GCIPL) were obtained using Heidelberg Spectralis. FreeSurfer7 was used to obtain the lateral geniculate nucleus (LGN), occipital volume fractions (to total estimated intracranial volume), and occipital cortical thickness. For the anterior visual pathway, the analysis was conducted using eyes, classified based on the history of ON (Eye-ON and Eye-NON) and compared with Eye-HC. The analysis of OCT and brain volumetric measures was conducted comparing MOGAD-ON, MOGAD-NON, and HC groups. The analysis of covariance with a Bonferroni-adjusted post hoc test was used to test differences between groups and linear regression analysis to evaluate OCT/MRI associations; age and sex were considered as covariates.
RESULTS RESULTS
24 (70.5%) patients had a prior ON. Median pRNFL and GCIPL thickness (um) was significantly reduced in Eye-ON vs EyeNON and HC (pRNFL: 69.4 (17.3), 89.6 (13.7), 98.2 (11.7),
DISCUSSION CONCLUSIONS
Compared with HC, MOGAD-ON exhibits reduced retinal thickness, primarily influenced by the presence and the number of prior ON episodes. Moreover, MOGAD-ON demonstrates significant atrophy in the retinal, subcortical, and cortical regions of the visual pathway, distinguishing them from MOGAD-NON and HC. These findings suggest that in patients with MOGAD neurodegeneration is tightly correlated with damage to the involved pathway.

Identifiants

DOI: 10.1212/WNL.0000000000209156 PMID: 38447105
pubmed: 38447105
doi: 10.1212/WNL.0000000000209156
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e209156

Auteurs

Luca Bollo (L)

From the Neurology Department (L.B., G.A., A.C.-C., J.V.A., S.C., J.C., I.G., L.S.M., B.R.A., A.Z., A.P., N.M.O., M.T., J.R., M.C., C.T., J.S.-G., X.M., A.V.-J.), Centro d'Esclerosi Múltiple de Catalunya (Cemcat); and Secció de Neuroradiologia (M.A., C.A., A.R., D.P.), Servei de Radiologia (IDI), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.
ORCID: 0000-0002-3673-2030

Georgina Arrambide (G)

From the Neurology Department (L.B., G.A., A.C.-C., J.V.A., S.C., J.C., I.G., L.S.M., B.R.A., A.Z., A.P., N.M.O., M.T., J.R., M.C., C.T., J.S.-G., X.M., A.V.-J.), Centro d'Esclerosi Múltiple de Catalunya (Cemcat); and Secció de Neuroradiologia (M.A., C.A., A.R., D.P.), Servei de Radiologia (IDI), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.
ORCID: 0000-0002-2657-5510

Alvaro Cobo-Calvo (A)

From the Neurology Department (L.B., G.A., A.C.-C., J.V.A., S.C., J.C., I.G., L.S.M., B.R.A., A.Z., A.P., N.M.O., M.T., J.R., M.C., C.T., J.S.-G., X.M., A.V.-J.), Centro d'Esclerosi Múltiple de Catalunya (Cemcat); and Secció de Neuroradiologia (M.A., C.A., A.R., D.P.), Servei de Radiologia (IDI), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.
ORCID: 0000-0002-2574-0721

Javier V Alvarez (JV)

From the Neurology Department (L.B., G.A., A.C.-C., J.V.A., S.C., J.C., I.G., L.S.M., B.R.A., A.Z., A.P., N.M.O., M.T., J.R., M.C., C.T., J.S.-G., X.M., A.V.-J.), Centro d'Esclerosi Múltiple de Catalunya (Cemcat); and Secció de Neuroradiologia (M.A., C.A., A.R., D.P.), Servei de Radiologia (IDI), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.

Manel Alberich (M)

From the Neurology Department (L.B., G.A., A.C.-C., J.V.A., S.C., J.C., I.G., L.S.M., B.R.A., A.Z., A.P., N.M.O., M.T., J.R., M.C., C.T., J.S.-G., X.M., A.V.-J.), Centro d'Esclerosi Múltiple de Catalunya (Cemcat); and Secció de Neuroradiologia (M.A., C.A., A.R., D.P.), Servei de Radiologia (IDI), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.

Sergio Cabello (S)

From the Neurology Department (L.B., G.A., A.C.-C., J.V.A., S.C., J.C., I.G., L.S.M., B.R.A., A.Z., A.P., N.M.O., M.T., J.R., M.C., C.T., J.S.-G., X.M., A.V.-J.), Centro d'Esclerosi Múltiple de Catalunya (Cemcat); and Secció de Neuroradiologia (M.A., C.A., A.R., D.P.), Servei de Radiologia (IDI), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.
ORCID: 0000-0002-4494-0761

Joaquín Castilló (J)

From the Neurology Department (L.B., G.A., A.C.-C., J.V.A., S.C., J.C., I.G., L.S.M., B.R.A., A.Z., A.P., N.M.O., M.T., J.R., M.C., C.T., J.S.-G., X.M., A.V.-J.), Centro d'Esclerosi Múltiple de Catalunya (Cemcat); and Secció de Neuroradiologia (M.A., C.A., A.R., D.P.), Servei de Radiologia (IDI), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.
ORCID: 0000-0002-8951-6315

Ingrid Galan (I)

From the Neurology Department (L.B., G.A., A.C.-C., J.V.A., S.C., J.C., I.G., L.S.M., B.R.A., A.Z., A.P., N.M.O., M.T., J.R., M.C., C.T., J.S.-G., X.M., A.V.-J.), Centro d'Esclerosi Múltiple de Catalunya (Cemcat); and Secció de Neuroradiologia (M.A., C.A., A.R., D.P.), Servei de Radiologia (IDI), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.

Luciana S Midaglia (LS)

From the Neurology Department (L.B., G.A., A.C.-C., J.V.A., S.C., J.C., I.G., L.S.M., B.R.A., A.Z., A.P., N.M.O., M.T., J.R., M.C., C.T., J.S.-G., X.M., A.V.-J.), Centro d'Esclerosi Múltiple de Catalunya (Cemcat); and Secció de Neuroradiologia (M.A., C.A., A.R., D.P.), Servei de Radiologia (IDI), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.

Breogan Rodriguez Acevedo (BR)

From the Neurology Department (L.B., G.A., A.C.-C., J.V.A., S.C., J.C., I.G., L.S.M., B.R.A., A.Z., A.P., N.M.O., M.T., J.R., M.C., C.T., J.S.-G., X.M., A.V.-J.), Centro d'Esclerosi Múltiple de Catalunya (Cemcat); and Secció de Neuroradiologia (M.A., C.A., A.R., D.P.), Servei de Radiologia (IDI), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.
ORCID: 0000-0002-0314-753X

Ana Zabalza (A)

From the Neurology Department (L.B., G.A., A.C.-C., J.V.A., S.C., J.C., I.G., L.S.M., B.R.A., A.Z., A.P., N.M.O., M.T., J.R., M.C., C.T., J.S.-G., X.M., A.V.-J.), Centro d'Esclerosi Múltiple de Catalunya (Cemcat); and Secció de Neuroradiologia (M.A., C.A., A.R., D.P.), Servei de Radiologia (IDI), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.
ORCID: 0000-0003-3860-5251

Agustin Pappolla (A)

From the Neurology Department (L.B., G.A., A.C.-C., J.V.A., S.C., J.C., I.G., L.S.M., B.R.A., A.Z., A.P., N.M.O., M.T., J.R., M.C., C.T., J.S.-G., X.M., A.V.-J.), Centro d'Esclerosi Múltiple de Catalunya (Cemcat); and Secció de Neuroradiologia (M.A., C.A., A.R., D.P.), Servei de Radiologia (IDI), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.
ORCID: 0000-0001-6364-9497

Neus Mongay Ochoa (N)

From the Neurology Department (L.B., G.A., A.C.-C., J.V.A., S.C., J.C., I.G., L.S.M., B.R.A., A.Z., A.P., N.M.O., M.T., J.R., M.C., C.T., J.S.-G., X.M., A.V.-J.), Centro d'Esclerosi Múltiple de Catalunya (Cemcat); and Secció de Neuroradiologia (M.A., C.A., A.R., D.P.), Servei de Radiologia (IDI), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.

Mar Tintore (M)

From the Neurology Department (L.B., G.A., A.C.-C., J.V.A., S.C., J.C., I.G., L.S.M., B.R.A., A.Z., A.P., N.M.O., M.T., J.R., M.C., C.T., J.S.-G., X.M., A.V.-J.), Centro d'Esclerosi Múltiple de Catalunya (Cemcat); and Secció de Neuroradiologia (M.A., C.A., A.R., D.P.), Servei de Radiologia (IDI), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.
ORCID: 0000-0001-9999-5359

Jordi Rio (J)

From the Neurology Department (L.B., G.A., A.C.-C., J.V.A., S.C., J.C., I.G., L.S.M., B.R.A., A.Z., A.P., N.M.O., M.T., J.R., M.C., C.T., J.S.-G., X.M., A.V.-J.), Centro d'Esclerosi Múltiple de Catalunya (Cemcat); and Secció de Neuroradiologia (M.A., C.A., A.R., D.P.), Servei de Radiologia (IDI), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.
ORCID: 0000-0003-4546-7627

Manuel Comabella (M)

From the Neurology Department (L.B., G.A., A.C.-C., J.V.A., S.C., J.C., I.G., L.S.M., B.R.A., A.Z., A.P., N.M.O., M.T., J.R., M.C., C.T., J.S.-G., X.M., A.V.-J.), Centro d'Esclerosi Múltiple de Catalunya (Cemcat); and Secció de Neuroradiologia (M.A., C.A., A.R., D.P.), Servei de Radiologia (IDI), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.

Carmen Tur (C)

From the Neurology Department (L.B., G.A., A.C.-C., J.V.A., S.C., J.C., I.G., L.S.M., B.R.A., A.Z., A.P., N.M.O., M.T., J.R., M.C., C.T., J.S.-G., X.M., A.V.-J.), Centro d'Esclerosi Múltiple de Catalunya (Cemcat); and Secció de Neuroradiologia (M.A., C.A., A.R., D.P.), Servei de Radiologia (IDI), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.
ORCID: 0000-0003-1849-3184

Cristina Auger (C)

From the Neurology Department (L.B., G.A., A.C.-C., J.V.A., S.C., J.C., I.G., L.S.M., B.R.A., A.Z., A.P., N.M.O., M.T., J.R., M.C., C.T., J.S.-G., X.M., A.V.-J.), Centro d'Esclerosi Múltiple de Catalunya (Cemcat); and Secció de Neuroradiologia (M.A., C.A., A.R., D.P.), Servei de Radiologia (IDI), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.
ORCID: 0000-0001-9846-4767

Jaume Sastre-Garriga (J)

From the Neurology Department (L.B., G.A., A.C.-C., J.V.A., S.C., J.C., I.G., L.S.M., B.R.A., A.Z., A.P., N.M.O., M.T., J.R., M.C., C.T., J.S.-G., X.M., A.V.-J.), Centro d'Esclerosi Múltiple de Catalunya (Cemcat); and Secció de Neuroradiologia (M.A., C.A., A.R., D.P.), Servei de Radiologia (IDI), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.
ORCID: 0000-0002-1589-2254

Alex Rovira (A)

From the Neurology Department (L.B., G.A., A.C.-C., J.V.A., S.C., J.C., I.G., L.S.M., B.R.A., A.Z., A.P., N.M.O., M.T., J.R., M.C., C.T., J.S.-G., X.M., A.V.-J.), Centro d'Esclerosi Múltiple de Catalunya (Cemcat); and Secció de Neuroradiologia (M.A., C.A., A.R., D.P.), Servei de Radiologia (IDI), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.
ORCID: 0000-0002-2132-6750

Xavier Montalban (X)

From the Neurology Department (L.B., G.A., A.C.-C., J.V.A., S.C., J.C., I.G., L.S.M., B.R.A., A.Z., A.P., N.M.O., M.T., J.R., M.C., C.T., J.S.-G., X.M., A.V.-J.), Centro d'Esclerosi Múltiple de Catalunya (Cemcat); and Secció de Neuroradiologia (M.A., C.A., A.R., D.P.), Servei de Radiologia (IDI), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.
ORCID: 0000-0002-0098-9918

Deborah Pareto (D)

From the Neurology Department (L.B., G.A., A.C.-C., J.V.A., S.C., J.C., I.G., L.S.M., B.R.A., A.Z., A.P., N.M.O., M.T., J.R., M.C., C.T., J.S.-G., X.M., A.V.-J.), Centro d'Esclerosi Múltiple de Catalunya (Cemcat); and Secció de Neuroradiologia (M.A., C.A., A.R., D.P.), Servei de Radiologia (IDI), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.

Angela Vidal-Jordana (A)

From the Neurology Department (L.B., G.A., A.C.-C., J.V.A., S.C., J.C., I.G., L.S.M., B.R.A., A.Z., A.P., N.M.O., M.T., J.R., M.C., C.T., J.S.-G., X.M., A.V.-J.), Centro d'Esclerosi Múltiple de Catalunya (Cemcat); and Secció de Neuroradiologia (M.A., C.A., A.R., D.P.), Servei de Radiologia (IDI), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.
ORCID: 0000-0002-7270-5507

Classifications MeSH