Male-female disparity in clinical features and significance of mild vertebral fractures in community-dwelling residents aged 50 and over.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
07 Mar 2024
07 Mar 2024
Historique:
received:
06
12
2023
accepted:
05
03
2024
medline:
8
3
2024
pubmed:
8
3
2024
entrez:
7
3
2024
Statut:
epublish
Résumé
This investigation examined the clinical implications of mild vertebral fractures in older community-dwelling residents. Focusing on the locomotion health of older individuals, the earlier reported Obuse study enrolled 415 randomly sampled Japanese residents aged between 50 and 89 years, 411 of whom underwent X-ray evaluations for pre-existing vertebral fractures. A blinded assessment of vertebral fractures based on Genant's criteria was conducted on the T5-L5 spine for rating on a severity scale. Grade 1 mild fractures were not linked to age in males, but increased with aging in females. Female participants had fewer Grade 1 and 2 fractures (P = 0.003 and 0.035, respectively) but more Grade 3 fractures (P = 0.013) than did males independently of age (Grade 1, 2, and 3: 25%, 16%, and 9% in females and 40%, 22%, and 6% in males, respectively). Weak negative correlations were observed between the number of fractures and bone mineral density in females for all fracture grades (Spearman's rho: 0.23 to 0.36, P < 0.05). Our study showed that Grade 1 mild vertebral fractures in males lacked pathological significance, while in females they potentially indicated fragility fractures and were related to poor lumbopelvic alignment.
Identifiants
pubmed: 38453997
doi: 10.1038/s41598-024-56379-6
pii: 10.1038/s41598-024-56379-6
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5602Subventions
Organisme : The Japan Orthopaedics and Traumatology Research Foundation, Inc
ID : 339
Informations de copyright
© 2024. The Author(s).
Références
Kammerlander, C. et al. Fragility fractures requiring special consideration: Vertebral fractures. Clin. Geriatr. Med. 30(2), 361–372 (2014).
doi: 10.1016/j.cger.2014.01.011
pubmed: 24721374
Al-Sari, U. A. et al. Health-related quality of life in older people with osteoporotic vertebral fractures: A systematic review and meta-analysis. Osteoporos. Int. 27(10), 2891–2900 (2016).
doi: 10.1007/s00198-016-3648-x
pubmed: 27262840
Stevenson, M. et al. Percutaneous vertebroplasty and percutaneous balloon kyphoplasty for the treatment of osteoporotic vertebral fractures: A systematic review and cost-effectiveness analysis. Health Technol. Assess. 18(17), 1–290 (2014).
doi: 10.3310/hta18170
pubmed: 24831822
pmcid: 4780997
Laura, I. et al. Which treatment to prevent an imminent fracture? Bone Rep. 15, 101105 (2021).
doi: 10.1016/j.bonr.2021.101105
pubmed: 34386562
pmcid: 8342786
Grados, F. et al. Influence of age and sex on vertebral shape indices assessed by radiographic morphometry. Osteoporos. Int. 10(6), 450–455 (1999).
doi: 10.1007/s001980050253
pubmed: 10663344
Leidig-Bruckner, G. et al. Sex difference in the validity of vertebral deformities as an index of prevalent vertebral osteoporotic fractures: A population survey of older men and women. Osteoporos. Int. 11(2), 102–119 (2000).
doi: 10.1007/PL00004172
pubmed: 10793868
Matsumoto, M. et al. Wedging of vertebral bodies at the thoracolumbar junction in asymptomatic healthy subjects on magnetic resonance imaging. Surg. Radiol. Anat. 33(3), 223–228 (2011).
doi: 10.1007/s00276-010-0746-x
pubmed: 21104252
Genant, H. K. et al. Vertebral fracture assessment using a semiquantitative technique. J. Bone Miner. Res. 8(9), 1137–1148 (1993).
doi: 10.1002/jbmr.5650080915
pubmed: 8237484
Ettinger, B. et al. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: Results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators. JAMA 282(7), 637–645 (1999).
doi: 10.1001/jama.282.7.637
pubmed: 10517716
Neer, R. M. et al. Effect of parathyroid hormone (1–34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N. Engl. J. Med. 344(19), 1434–1441 (2001).
doi: 10.1056/NEJM200105103441904
pubmed: 11346808
Uehara, M. et al. Sagittal spinal alignment deviation in the general elderly population: A Japanese cohort survey randomly sampled from a basic resident registry. Spine J. 19(2), 349–356 (2019).
doi: 10.1016/j.spinee.2018.06.346
pubmed: 29959097
Baddoura, R. et al. Osteoporotic fractures, DXA, and fracture risk assessment: Meeting future challenges in the Eastern Mediterranean Region. J. Clin. Densitom. 14(4), 384–394 (2011).
doi: 10.1016/j.jocd.2011.03.009
pubmed: 21839659
Barake, M. et al. Osteoporotic hip and vertebral fractures in the Arab region: A systematic review. Osteoporos. Int. 32(8), 1499–1515 (2021).
doi: 10.1007/s00198-021-05937-z
pubmed: 33825915
Marshall, D. et al. Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ 312(7041), 1254–1259 (1996).
doi: 10.1136/bmj.312.7041.1254
pubmed: 8634613
pmcid: 2351094
Najjar, E. et al. The influence of osteoporotic vertebral fractures on global sagittal alignment in elderly patients: A systematic review and meta-analysis. Eur. Spine J. 32(7), 2580–2587 (2023).
doi: 10.1007/s00586-023-07780-8
pubmed: 37222801
Papaioannou, A. et al. The impact of incident fractures on health-related quality of life: 5 years of data from the Canadian Multicentre Osteoporosis Study. Osteoporos. Int. 20(5), 703–714 (2009).
doi: 10.1007/s00198-008-0743-7
pubmed: 18802659
Fujiwara, S. et al. Fracture prediction from bone mineral density in Japanese men and women. J. Bone Miner. Res. 18(8), 1547–1553 (2003).
doi: 10.1359/jbmr.2003.18.8.1547
pubmed: 12929946
Liu, G. et al. Effect of osteoarthritis in the lumbar spine and hip on bone mineral density and diagnosis of osteoporosis in elderly men and women. Osteoporos. Int. 7(6), 564–569 (1997).
doi: 10.1007/BF02652563
pubmed: 9604053
Oe, S. et al. The influence of age and sex on cervical spinal alignment among volunteers aged over 50. Spine 40(19), 1487–1494 (2015).
doi: 10.1097/BRS.0000000000001071
pubmed: 26208229
Asai, Y. et al. Sagittal spino-pelvic alignment in adults: The Wakayama spine study. PLoS ONE 12(6), e0178697 (2017).
doi: 10.1371/journal.pone.0178697
pubmed: 28586366
pmcid: 5460860
Ikegami, S. et al. Cervical spinal alignment change accompanying spondylosis exposes harmonization failure with total spinal balance: A Japanese cohort survey randomly sampled from a basic resident registry. J. Clin. Med. 10(24), 5737 (2021).
doi: 10.3390/jcm10245737
pubmed: 34945033
pmcid: 8706315
Tokida, R. et al. Association between sagittal spinal alignment and physical function in the Japanese general elderly population: A Japanese cohort survey randomly sampled from a basic resident registry. J. Bone Jt. Surg. Am. 101(18), 1698–1706 (2019).
doi: 10.2106/JBJS.18.01384
Nishimura, H. et al. Detection of cognitive decline by spinal posture assessment in health exams of the general older population. Sci. Rep. 12(1), 8460 (2022).
doi: 10.1038/s41598-022-12605-7
pubmed: 35589972
pmcid: 9120125