Sex and HIV Differences in Preserved Ratio Impaired Spirometry (PRISm) Among Ugandans Postpneumonia.

HIV preserved ratio impaired spirometry sex differences tuberculosis

Journal

Open forum infectious diseases
ISSN: 2328-8957
Titre abrégé: Open Forum Infect Dis
Pays: United States
ID NLM: 101637045

Informations de publication

Date de publication:
Mar 2024
Historique:
received: 21 06 2023
accepted: 18 01 2024
medline: 8 3 2024
pubmed: 8 3 2024
entrez: 8 3 2024
Statut: epublish

Résumé

Preserved ratio impaired spirometry (PRISm), defined as a normal ratio of forced expiratory volume in 1 second (FEV Adults with and without HIV underwent baseline followed by serial spirometry after completing therapy for pneumonia, predominantly tuberculosis (TB), in Kampala, Uganda. Using generalized estimating equations adjusted for age, body mass index, smoking, biomass fuel exposure, HIV, and TB status, we compared individuals with PRISm with those with normal spirometry. These models were stratified by HIV status. Of 339 baseline participants, 153 (45%) were women; 129 (38%) had HIV, of whom 53% were women. Overall, 105/339 participants (31%) had PRISm at baseline. HIV was associated with lower odds of PRISm (adjusted odds ratio [aOR], 0.38; 95% CI, 0.21-0.68; Among Ugandan adults who recovered from pneumonia, female sex was associated with increased odds and HIV with decreased odds of PRISm, suggesting independent sex and HIV effects on PRISm pathogenesis.

Sections du résumé

Background UNASSIGNED
Preserved ratio impaired spirometry (PRISm), defined as a normal ratio of forced expiratory volume in 1 second (FEV
Methods UNASSIGNED
Adults with and without HIV underwent baseline followed by serial spirometry after completing therapy for pneumonia, predominantly tuberculosis (TB), in Kampala, Uganda. Using generalized estimating equations adjusted for age, body mass index, smoking, biomass fuel exposure, HIV, and TB status, we compared individuals with PRISm with those with normal spirometry. These models were stratified by HIV status.
Results UNASSIGNED
Of 339 baseline participants, 153 (45%) were women; 129 (38%) had HIV, of whom 53% were women. Overall, 105/339 participants (31%) had PRISm at baseline. HIV was associated with lower odds of PRISm (adjusted odds ratio [aOR], 0.38; 95% CI, 0.21-0.68;
Conclusions UNASSIGNED
Among Ugandan adults who recovered from pneumonia, female sex was associated with increased odds and HIV with decreased odds of PRISm, suggesting independent sex and HIV effects on PRISm pathogenesis.

Identifiants

DOI: 10.1093/ofid/ofae033 PMID: 38456193 PMC: PMC10919919
pubmed: 38456193
doi: 10.1093/ofid/ofae033
pii: ofae033
pmc: PMC10919919
doi:

Types de publication

Journal Article

Langues

eng

Pagination

ofae033

Informations de copyright

© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

Déclaration de conflit d'intérêts

Potential conflicts of interest. The authors have no conflicts of interest.

Auteurs

Rebecca A Abelman (RA)

Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
ORCID: 0000-0003-3040-1879

Jessica Fitzpatrick (J)

Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.

Katerina L Byanova (KL)

Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.

Josephine Zawedde (J)

Infectious Diseases Research Collaboration, Kampala, Uganda.

Ingvar Sanyu (I)

Infectious Diseases Research Collaboration, Kampala, Uganda.

Patrick Byanyima (P)

Infectious Diseases Research Collaboration, Kampala, Uganda.

Emmanuel Musisi (E)

Division of Infection and Global Health, School of Medicine, University of St. Andrews, St. Andrews, UK.

Jenny Hsieh (J)

Department of Anesthesia and Critical Care, University of California San Francisco, San Francisco, California, USA.

Michelle Zhang (M)

Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.

Jake Branchini (J)

Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.

Abdul Sessolo (A)

Infectious Diseases Research Collaboration, Kampala, Uganda.

Peter W Hunt (PW)

Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
ORCID: 0000-0002-4571-4870

Rejani Lalitha (R)

Division of Pulmonary Medicine, Department of Medicine, Makerere College of Health Sciences, Kampala, Uganda.

J Lucian Davis (JL)

Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA.
Pulmonary, Critical Care, and Sleep Medicine Section, Yale School of Medicine, New Haven, Connecticut, USA.

Kristina Crothers (K)

Division of Pulmonary, Critical Care and Sleep, Department of Medicine, Veterans Affairs (VA) Puget Sound Health Care System and University of Washington, Seattle, Washington, USA.

William Worodria (W)

Division of Pulmonary Medicine, Department of Medicine, Makerere College of Health Sciences, Kampala, Uganda.
Division of Pulmonary Medicine, Department of Medicine, Mulago Hospital and Complex, Kampala, Uganda.

Laurence Huang (L)

Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.

Classifications MeSH