Prevalence of orthostatic intolerance in long covid clinic patients and healthy volunteers: A multicenter study.
NASA lean test
PoTS
dysautonomia
long covid
orthostatic hypotension
orthostatic tachycardia
Journal
Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876
Informations de publication
Date de publication:
Mar 2024
Mar 2024
Historique:
revised:
29
01
2024
received:
27
12
2023
accepted:
13
02
2024
medline:
8
3
2024
pubmed:
8
3
2024
entrez:
8
3
2024
Statut:
ppublish
Résumé
Orthostatic intolerance (OI), including postural orthostatic tachycardia syndrome (PoTS) and orthostatic hypotension (OH), are often reported in long covid, but published studies are small with inconsistent results. We sought to estimate the prevalence of objective OI in patients attending long covid clinics and healthy volunteers and associations with OI symptoms and comorbidities. Participants with a diagnosis of long covid were recruited from eight UK long covid clinics, and healthy volunteers from general population. All undertook standardized National Aeronautics and Space Administration Lean Test (NLT). Participants' history of typical OI symptoms (e.g., dizziness, palpitations) before and during the NLT were recorded. Two hundred seventy-seven long covid patients and 50 frequency-matched healthy volunteers were tested. Healthy volunteers had no history of OI symptoms or symptoms during NLT or PoTS, 10% had asymptomatic OH. One hundred thirty (47%) long covid patients had previous history of OI symptoms and 144 (52%) developed symptoms during the NLT. Forty-one (15%) had an abnormal NLT, 20 (7%) met criteria for PoTS, and 21 (8%) had OH. Of patients with an abnormal NLT, 45% had no prior symptoms of OI. Relaxing the diagnostic thresholds for PoTS from two consecutive abnormal readings to one abnormal reading during the NLT, resulted in 11% of long covid participants (an additional 4%) meeting criteria for PoTS, but not in healthy volunteers. More than half of long covid patients experienced OI symptoms during NLT and more than one in 10 patients met the criteria for either PoTS or OH, half of whom did not report previous typical OI symptoms. We therefore recommend all patients attending long covid clinics are offered an NLT and appropriate management commenced.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e29486Subventions
Organisme : National Institute for Health and Care Research
Investigateurs
Adam Mosley
(A)
Amy Parkin
(A)
Amy Rebane
(A)
Ashliegh Lovett
(A)
Carlos Echevarria
(C)
Clare Rayner
(C)
Darren Winch
(D)
Ghazala Mir
(G)
Ian Tucker-Bell
(I)
Juliet Harris
(J)
Karen Cook
(K)
Madeline Goodwin
(M)
Megan Ball
(M)
Nawar Bakerly
(N)
Nikki Smith
(N)
Rachael Evans
(R)
Ruairidh Milne
(R)
Samantha Jones
(S)
Sarah Elkin
(S)
Sophie Evans
(S)
Stephen Halpin
(S)
Zacchaeus Falope
(Z)
Informations de copyright
© 2024 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC.
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