Poly(d-amino acid) Nanoparticles Target

Staphylococcal biofilm disassembly peptidoglycan binding protein 4 peptidoglycan insertion poly(d-amino acid) nanoparticles transpeptidation

Journal

ACS nano
ISSN: 1936-086X
Titre abrégé: ACS Nano
Pays: United States
ID NLM: 101313589

Informations de publication

Date de publication:
19 Mar 2024
Historique:
pubmed: 8 3 2024
medline: 8 3 2024
entrez: 8 3 2024
Statut: ppublish

Résumé

d-Amino acids are signals for biofilm disassembly. However, unexpected metabolic pathways severely attenuate the utilization of d-amino acids in biofilm disassembly, resulting in unsatisfactory efficiency. Herein, three-dimensional poly(d-amino acid) nanoparticles (NPs), which possess the ability to block intracellular metabolism, are constructed with the aim of disassembling the biofilms. The obtained poly(α-

Identifiants

DOI: 10.1021/acsnano.3c10983 PMID: 38456817
pubmed: 38456817
doi: 10.1021/acsnano.3c10983
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

8017-8028

Auteurs

Wenli Feng (W)

State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, People's Republic of China.
AO Research Institute Davos, Davos 7270, Switzerland.
China-Japan Friendship Hospital, Beijing 100029, People's Republic of China.

Marco Chittò (M)

AO Research Institute Davos, Davos 7270, Switzerland.

Wensheng Xie (W)

State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, People's Republic of China.

Qun Ren (Q)

The Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Biointerfaces, EMPA, Lerchenfeldstrasse 5, 9014 St. Gallen, Switzerland.
ORCID: 0000-0003-0627-761X

Fang Liu (F)

China-Japan Friendship Hospital, Beijing 100029, People's Republic of China.

Xiaoxu Kang (X)

State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, People's Republic of China.

Dongdong Zhao (D)

State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, People's Republic of China.

Guofeng Li (G)

State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, People's Republic of China.
ORCID: 0000-0002-4101-0059

Thomas Fintan Moriarty (TF)

AO Research Institute Davos, Davos 7270, Switzerland.
ORCID: 0000-0003-2307-0397

Xing Wang (X)

State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, People's Republic of China.
ORCID: 0000-0002-9990-1479

Classifications MeSH