The role of pyroptosis in viral infection.
Journal
Archives of virology
ISSN: 1432-8798
Titre abrégé: Arch Virol
Pays: Austria
ID NLM: 7506870
Informations de publication
Date de publication:
08 Mar 2024
08 Mar 2024
Historique:
received:
07
09
2023
accepted:
17
12
2023
medline:
11
3
2024
pubmed:
8
3
2024
entrez:
8
3
2024
Statut:
epublish
Résumé
Pyroptosis, also known as inflammatory necrosis, is a form of programmed cell death, which is an important natural immune response. Pyroptosis plays a major role in combating pathogenic infections. The mechanism of pyroptosis is distinct from other forms of cell death and is characterized by its dependence on inflammatory caspases (mainly caspases 1, 4, 5, and 11). Activation of NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammatory vesicles is involved in caspase-1 activation and cleavage, which in turn triggers cleavage and multimerization of multiple gasdermin family members, including gasdermin-D (GSDMD). This further leads to cell perforation and cellular distension, causing cell membrane rupture, resulting in a massive efflux of cell contents, which triggers inflammatory reactions. In recent years, detailed study of viral diseases, has demonstrated that pyroptosis is closely associated with the development of viral diseases. This article focuses on the mechanism of pyroptosis and the connection between pyroptosis and viral infection.
Identifiants
pubmed: 38456965
doi: 10.1007/s00705-024-05978-9
pii: 10.1007/s00705-024-05978-9
doi:
Substances chimiques
Intracellular Signaling Peptides and Proteins
0
Gasdermins
0
Neoplasm Proteins
0
Caspases
EC 3.4.22.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
69Subventions
Organisme : Natural Science Foundation of Shandong Province
ID : ZR2020MH302
Organisme : Natural Science Foundation of Shandong Province
ID : ZR2020MC020
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.
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