Chromosomal R-loops: who R they?

R-loop disorder R-loop regulator R-loop screen RNA-DNA hybrid

Journal

Biologia futura

ISSN: 2676-8607

Titre abrégé: Biol Futur

Pays: Switzerland

ID NLM: 101738236

Informations de publication

Date de publication:
08 Mar 2024

Historique:

received: 19 11 2023

accepted: 14 02 2024

medline: 8 3 2024

pubmed: 8 3 2024

entrez: 8 3 2024

Statut: aheadofprint

Résumé

R-loops, composed of DNA-RNA hybrids and displaced single-stranded DNA, are known to pose a severe threat to genome integrity. Therefore, extensive research has focused on identifying regulatory proteins involved in controlling R-loop levels. These proteins play critical roles in preventing R-loop accumulation and associated genome instability. Herein I summarize recent knowledge on R-loop regulators affecting R-loop homeostasis, involving a wide array of R-loop screening methods that have enabled their characterization, from forward genetic and siRNA-based screens to proximity labeling and machine learning. These approaches not only deepen our understanding on R-loop formation processes, but also hold promise to find new targets in R-loop dysregulation associated with human pathologies.

Identifiants

DOI: 10.1007/s42977-024-00213-7 PMID: 38457033

pubmed: 38457033

doi: 10.1007/s42977-024-00213-7

pii: 10.1007/s42977-024-00213-7

doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

Subventions

Organisme : National Research, Development and Innovation Office

ID : NKFIH-NNE-130913

Informations de copyright

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