Workflow to facilitate the detection of new psychoactive substances and drugs of abuse in influent urban wastewater.

High-resolution mass spectrometry Illicit drugs New Psychoactive Substances Suspect screening Wastewater-based epidemiology

Journal

Journal of hazardous materials
ISSN: 1873-3336
Titre abrégé: J Hazard Mater
Pays: Netherlands
ID NLM: 9422688

Informations de publication

Date de publication:
05 Mar 2024
Historique:
received: 19 12 2023
revised: 22 02 2024
accepted: 03 03 2024
medline: 9 3 2024
pubmed: 9 3 2024
entrez: 8 3 2024
Statut: aheadofprint

Résumé

The complexity around the dynamic markets for new psychoactive substances (NPS) forces researchers to develop and apply innovative analytical strategies to detect and identify them in influent urban wastewater. In this work a comprehensive suspect screening workflow following liquid chromatography - high resolution mass spectrometry analysis was established utilising the open-source InSpectra data processing platform and the HighResNPS library. In total, 278 urban influent wastewater samples from 47 sites in 16 countries were collected to investigate the presence of NPS and other drugs of abuse. A total of 50 compounds were detected in samples from at least one site. Most compounds found were prescription drugs such as gabapentin (detection frequency 79%), codeine (40%) and pregabalin (15%). However, cocaine was the most found illicit drug (83%), in all countries where samples were collected apart from the Republic of Korea and China. Eight NPS were also identified with this protocol: 3-methylmethcathinone 11%), eutylone (6%), etizolam (2%), 3-chloromethcathinone (4%), mitragynine (6%), phenibut (2%), 25I-NBOH (2%) and trimethoxyamphetamine (2%). The latter three have not previously been reported in municipal wastewater samples. The workflow employed allowed the prioritisation of features to be further investigated, reducing processing time and gaining in confidence in their identification.

Identifiants

DOI: 10.1016/j.jhazmat.2024.133955 PMID: 38457976
pubmed: 38457976
pii: S0304-3894(24)00534-X
doi: 10.1016/j.jhazmat.2024.133955
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

133955

Informations de copyright

Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Richard Bade (R)

Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 20 Cornwall Street, Woolloongabba, Queensland 4102, Australia. Electronic address: r.bade@uq.edu.au.

Denice van Herwerden (D)

Van't Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, the Netherlands.

Nikolaos Rousis (N)

Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 20 Cornwall Street, Woolloongabba, Queensland 4102, Australia.

Sangeet Adhikari (S)

School of Sustainable Engineering and Built Environment, Arizona State University, Tempe, AZ 85281, United States; Biodesign Center for Environmental Health Engineering, Biodesign Institute, Arizona State University, 1001 S. McAllister Ave., Tempe, AZ 85281, United States.

Darren Allen (D)

Royal Brisbane and Women's Hospital, Herston, QLD 4029, Australia.

Christine Baduel (C)

Université Grenoble Alpes, CNRS, IRD, Grenoble INP, Institute of Environmental Geosciences (IGE), Grenoble, France.

Lubertus Bijlsma (L)

Environmental and Public Health Analytical Chemistry, Research Institute for Pesticides and Water, University Jaume I, Avda, Sos Baynat s/n, E-12071 Castellón, Spain.

Tim Boogaerts (T)

Toxicological Centre, Department of Pharmaceutical Sciences, University of Antwerp, 2610 Wilrijk, Belgium.

Dan Burgard (D)

Department of Chemistry and Biochemistry, University of Puget Sound, Tacoma, WA 98416, United States.

Andrew Chappell (A)

Institute of Environmental Science and Research Limited (ESR), Christchurch Science Centre, 27 Creyke Road, Ilam, Christchurch 8041, New Zealand.

Erin M Driver (EM)

Biodesign Center for Environmental Health Engineering, Biodesign Institute, Arizona State University, 1001 S. McAllister Ave., Tempe, AZ 85281, United States.

Fernando Fabriz Sodre (FF)

Institute of Chemistry, University of Brasília, Brasília, DF 70910-000, Brazil.

Despo Fatta-Kassinos (D)

Nireas-International Water Research Centre and Department of Civil and Environmental Engineering, University of Cyprus, P.O. Box 20537, 1678 Nicosia, Cyprus.

Emma Gracia-Lor (E)

Department of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid, Avenida Complutense s/n, 28040 Madrid, Spain.

Elisa Gracia-Marín (E)

Environmental and Public Health Analytical Chemistry, Research Institute for Pesticides and Water, University Jaume I, Avda, Sos Baynat s/n, E-12071 Castellón, Spain.

Rolf U Halden (RU)

School of Sustainable Engineering and Built Environment, Arizona State University, Tempe, AZ 85281, United States; Biodesign Center for Environmental Health Engineering, Biodesign Institute, Arizona State University, 1001 S. McAllister Ave., Tempe, AZ 85281, United States; OneWaterOneHealth, Arizona State University Foundation, 1001 S. McAllister Avenue, Tempe, AZ 85287-8101, United States.

Ester Heath (E)

Jožef Stefan Institute and International Postgraduate School Jožef Stefan, Jamova 39, 1000 Ljubljana, Slovenia.

Emma Jaunay (E)

Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide 5001, South Australia, Australia.

Alex Krotulski (A)

Center for Forensic Science Research and Education, Fredric Rieders Family Foundation, Willow Grove, PA 19090, United States.

Foon Yin Lai (FY)

Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences (SLU), SE-75007 Uppsala, Sweden.

Arndís Sue Ching Löve (ASC)

University of Iceland, Department of Pharmacology and Toxicology, Hofsvallagata 53, 107 Reykjavik, Iceland; University of Iceland, Faculty of Pharmaceutical Sciences, Hofsvallagata 53, 107 Reykjavik, Iceland.

Jake W O'Brien (JW)

Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 20 Cornwall Street, Woolloongabba, Queensland 4102, Australia; Van't Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, the Netherlands.

Jeong-Eun Oh (JE)

Department of Civil and Environmental Engineering, Pusan National University, Jangjeon-dong, Geumjeong-gu, Busan 46241, Republic of Korea.

Daniel Pasin (D)

Forensic Laboratory Division, San Francisco Office of the Chief Medical Examiner, 1 Newhall St, San Francisco, CA 94124, United States.

Marco Pineda Castro (MP)

Department of Chemical Engineering, McGill University, Montreal, QC, Canada.

Magda Psichoudaki (M)

Nireas-International Water Research Centre and Department of Civil and Environmental Engineering, University of Cyprus, P.O. Box 20537, 1678 Nicosia, Cyprus.

Noelia Salgueiro-Gonzalez (N)

Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Department of Environmental Health Sciences, Via Mario Negri 2, 20156 Milan, Italy.

Cezar Silvino Gomes (CS)

Laboratory of Forensic Chemistry, Brazilian Federal Police, PB, Brazil.

Bikram Subedi (B)

Department of Chemistry, Murray State University, Murray, KY 42071-3300, United States.

Kevin V Thomas (KV)

Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 20 Cornwall Street, Woolloongabba, Queensland 4102, Australia.

Nikolaos Thomaidis (N)

Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.

Degao Wang (D)

College of Environmental Science and Engineering, Dalian Maritime University, No. 1 Linghai Road, Dalian 116026, PR China.

Viviane Yargeau (V)

Department of Chemical Engineering, McGill University, Montreal, QC, Canada.

Saer Samanipour (S)

Van't Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, the Netherlands; UvA Data Science Center, University of Amsterdam, the Netherlands.

Jochen Mueller (J)

Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 20 Cornwall Street, Woolloongabba, Queensland 4102, Australia.

Classifications MeSH