Organization of reward and movement signals in the basal ganglia and cerebellum.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
08 Mar 2024
Historique:
received: 05 11 2022
accepted: 06 02 2024
medline: 9 3 2024
pubmed: 9 3 2024
entrez: 8 3 2024
Statut: epublish

Résumé

The basal ganglia and the cerebellum are major subcortical structures in the motor system. The basal ganglia have been cast as the reward center of the motor system, whereas the cerebellum is thought to be involved in adjusting sensorimotor parameters. Recent findings of reward signals in the cerebellum have challenged this dichotomous view. To compare the basal ganglia and the cerebellum directly, we recorded from oculomotor regions in both structures from the same monkeys. We partitioned the trial-by-trial variability of the neurons into reward and eye-movement signals to compare the coding across structures. Reward expectation and movement signals were the most pronounced in the output structure of the basal ganglia, intermediate in the cerebellum, and the smallest in the input structure of the basal ganglia. These findings suggest that reward and movement information is sharpened through the basal ganglia, resulting in a higher signal-to-noise ratio than in the cerebellum.

Identifiants

pubmed: 38459003
doi: 10.1038/s41467-024-45921-9
pii: 10.1038/s41467-024-45921-9
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2119

Subventions

Organisme : EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)
ID : 755745
Organisme : Israel Science Foundation (ISF)
ID : 380/17

Informations de copyright

© 2024. The Author(s).

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Auteurs

Noga Larry (N)

Edmond and Lily Safra Center for Brain Sciences, the Hebrew University, Jerusalem, Israel. noga.larry@mail.huji.ac.il.

Gil Zur (G)

Edmond and Lily Safra Center for Brain Sciences, the Hebrew University, Jerusalem, Israel.

Mati Joshua (M)

Edmond and Lily Safra Center for Brain Sciences, the Hebrew University, Jerusalem, Israel. mati.joshua@mail.huji.ac.il.

Classifications MeSH