Structural basis for self-discrimination by neoantigen-specific TCRs.

Animals Mice Receptors, Antigen, T-Cell / metabolism Melanoma / genetics Mutation Epitopes, T-Lymphocyte

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
08 Mar 2024
Historique:
received: 13 01 2023
accepted: 26 02 2024
medline: 11 3 2024
pubmed: 9 3 2024
entrez: 8 3 2024
Statut: epublish

Résumé

T cell receptors (TCR) are pivotal in mediating tumour cell cytolysis via recognition of mutation-derived tumour neoantigens (neoAgs) presented by major histocompatibility class-I (MHC-I). Understanding the factors governing the emergence of neoAg from somatic mutations is a major focus of current research. However, the structural and cellular determinants controlling TCR recognition of neoAgs remain poorly understood. This study describes the multi-level analysis of a model neoAg from the B16F10 murine melanoma, H2-D

Identifiants

DOI: 10.1038/s41467-024-46367-9 PMID: 38459027 PMC: PMC10924104
pubmed: 38459027
doi: 10.1038/s41467-024-46367-9
pii: 10.1038/s41467-024-46367-9
pmc: PMC10924104
doi:

Substances chimiques

Receptors, Antigen, T-Cell 0
Epitopes, T-Lymphocyte 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2140

Subventions

Organisme : NCI NIH HHS
ID : P30 CA016087
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA214354
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA225450
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM124489
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA243486
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI078892
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA078207
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA201189
Pays : United States

Commentaires et corrections

Type : UpdateOf

Informations de copyright

© 2024. The Author(s).

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Auteurs

John P Finnigan (JP)

Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Pl., New York, NY, USA.
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave., New York, NY, USA.
Department of Medicine, Division of Hematology and Medical Oncology, Mount Sinai Hospital, New York, NY, USA.
Department of Surgery, Division of Thoracic and Cardiac Surgery, Brigham and Women's Hospital, 75 Francis St., Boston, MA, USA.

Jenna H Newman (JH)

Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Pl., New York, NY, USA.
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave., New York, NY, USA.
Department of Medicine, Division of Hematology and Medical Oncology, Mount Sinai Hospital, New York, NY, USA.

Yury Patskovsky (Y)

Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health, New York, NY, USA.

Larysa Patskovska (L)

Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health, New York, NY, USA.

Andrew S Ishizuka (AS)

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Barinthus Biotherapeutics, Germantown, MD, USA.

Geoffrey M Lynn (GM)

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Barinthus Biotherapeutics, Germantown, MD, USA.

Robert A Seder (RA)

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
ORCID: 0000-0003-3133-0849

Michelle Krogsgaard (M)

Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA. michelle.krogsgaard@nyulangone.org.
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health, New York, NY, USA. michelle.krogsgaard@nyulangone.org.
ORCID: 0000-0001-5006-7981

Nina Bhardwaj (N)

Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Pl., New York, NY, USA. nina.bhardwaj@mssm.edu.
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave., New York, NY, USA. nina.bhardwaj@mssm.edu.
Department of Medicine, Division of Hematology and Medical Oncology, Mount Sinai Hospital, New York, NY, USA. nina.bhardwaj@mssm.edu.
Parker Institute for Cancer Immunotherapy, Francisco, CA, USA. nina.bhardwaj@mssm.edu.
ORCID: 0000-0003-1865-4187

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Structural basis for self-discrimination by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Structural basis for self-discrimination by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › Structural basis for self-discrimination by...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Naevus et mélanomes › Mélanome › Structural basis for self-discrimination by...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Structural basis for self-discrimination by...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Épitopes › Déterminants antigéniques des lymphocytes T › Structural basis for self-discrimination by...