Tick hemocytes have a pleiotropic role in microbial infection and arthropod fitness.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
08 Mar 2024
08 Mar 2024
Historique:
received:
20
10
2023
accepted:
28
02
2024
medline:
11
3
2024
pubmed:
9
3
2024
entrez:
8
3
2024
Statut:
epublish
Résumé
Uncovering the complexity of systems in non-model organisms is critical for understanding arthropod immunology. Prior efforts have mostly focused on Dipteran insects, which only account for a subset of existing arthropod species in nature. Here we use and develop advanced techniques to describe immune cells (hemocytes) from the clinically relevant tick Ixodes scapularis at a single-cell resolution. We observe molecular alterations in hemocytes upon feeding and infection with either the Lyme disease spirochete Borrelia burgdorferi or the rickettsial agent Anaplasma phagocytophilum. We reveal hemocyte clusters exhibiting defined signatures related to immunity, metabolism, and proliferation. Depletion of phagocytic hemocytes affects hemocytin and astakine levels, two I. scapularis hemocyte markers, impacting blood-feeding, molting behavior, and bacterial acquisition. Mechanistically, astakine alters hemocyte proliferation, whereas hemocytin affects the c-Jun N-terminal kinase (JNK) signaling pathway in I. scapularis. Altogether, we discover a role for tick hemocytes in immunophysiology and provide a valuable resource for comparative biology in arthropods.
Identifiants
pubmed: 38459063
doi: 10.1038/s41467-024-46494-3
pii: 10.1038/s41467-024-46494-3
pmc: PMC10923820
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2117Subventions
Organisme : NIAID NIH HHS
ID : F31 AI152215
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI162579
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI138949
Pays : United States
Organisme : NIAID NIH HHS
ID : F31 AI167471
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI168592
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI116523
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI134696
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© 2024. The Author(s).
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