Axicabtagene ciloleucel treatment is more effective in primary mediastinal large B-cell lymphomas than in diffuse large B-cell lymphomas: the Italian CART-SIE study.


Journal

Leukemia
ISSN: 1476-5551
Titre abrégé: Leukemia
Pays: England
ID NLM: 8704895

Informations de publication

Date de publication:
08 Mar 2024
Historique:
received: 07 11 2023
accepted: 28 02 2024
revised: 27 02 2024
medline: 9 3 2024
pubmed: 9 3 2024
entrez: 8 3 2024
Statut: aheadofprint

Résumé

Axicabtagene ciloleucel showed efficacy for relapsed/refractory large B-cell lymphomas (LBCL), including primary mediastinal B-cell lymphomas (PMBCL); however, only few PMBCLs were reported. Aim was to evaluate efficacy and safety of axicabtagene ciloleucel in patients with PMBCL compared to those with other LBCL, enrolled in the Italian prospective observational CART-SIE study. PMBCLs (n = 70) were younger, with higher percentage of bulky and refractory disease, compared to other LBCLs (n = 190). Median follow-up time for infused patients was 12.17 months (IQR 5.53,22.73). The overall (complete + partial) response rate (ORR,CR + PR) after bridging was 41% for PMBCL and 28% for other LBCL, p = 0.0102. Thirty days ORR was 78% (53/68) with 50% (34) CR in PMBCL, and 75% (141/187) with 53% (100) CR in other LBCL, p = 0.5457. Ninety days ORR was 69% (45/65) with 65% (42) CR in PMBCL, and 54% (87/162) with 47% (76) CR in other LBCL; progressive disease was 21% in PMBCL and 45% in other LBCL, p = 0.0336. Twelve months progression-free survival was 62% (95% CI: 51-75) in PMBCL versus 48% (95% CI: 41-57) in other LBCL, p = 0.0386. Twelve months overall survival was 86% (95% CI: 78-95) in PMBCL versus 71% (95% CI: 64-79) in other LBCL, p = 0.0034. All grade cytokine release syndrome was 88% (228/260); all grade neurotoxicity was 34% (88/260), with 6% of fatal events in PMBCL. Non-relapse mortality was 3%. In conclusion, PMBCLs achieved significantly better response and survival rates than other LBCLs.

Identifiants

pubmed: 38459167
doi: 10.1038/s41375-024-02213-x
pii: 10.1038/s41375-024-02213-x
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Ministero della Salute (Ministry of Health, Italy)
ID : #PNC-E3-2022-23683269-PNC-HLS-TA
Organisme : Ministero della Salute (Ministry of Health, Italy)
ID : "Ricerca Finalizzata 2019" #RF-2019-12370243

Informations de copyright

© 2024. The Author(s).

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Auteurs

Annalisa Chiappella (A)

Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy. annalisa.chiappella@istitutotumori.mi.it.

Beatrice Casadei (B)

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy.

Patrizia Chiusolo (P)

Department of Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.

Alice Di Rocco (A)

Hematology Section, Department of Translational and Precision Medicine, "Sapienza" University of Rome, Roma, Italy.

Silva Ljevar (S)

Unit of Biostatistics for Clinical Research, Department of Data Science, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.

Martina Magni (M)

Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.

Piera Angelillo (P)

Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy.

Anna Maria Barbui (AM)

Department of Oncology and Hematology, Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.

Ilaria Cutini (I)

SOD Terapie Cellulari e Medicina Trasfusionale, Azienda Ospedaliero-Universitaria Careggi, Firenze, Italy.

Anna Dodero (A)

Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.

Francesca Bonifazi (F)

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy.

Maria Chiara Tisi (MC)

Hematology Unit, San Bortolo Hospital, A.U.L.S.S. 8 "Berica", Vicenza, Italy.

Stefania Bramanti (S)

Department of Oncology/Hematology, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy.

Maurizio Musso (M)

UOC di oncoematologia e TMO "La Maddalena", Palermo, Italy.

Mirko Farina (M)

Unit of Blood Disease and Bone Marrow Transplantation, and Unit of Hematology, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy.

Massimo Martino (M)

Stem Cell Transplantation and Cellular Therapies Unit (CTMO), Department of Hemato-Oncology and Radiotherapy, Grande Ospedale Metropolitano "Bianchi-Melacrino-Morelli", Reggio Calabria, Italy.

Mattia Novo (M)

Division of Hematology, Città della Salute e della Scienza Hospital and University, Torino, Italy.

Giovanni Grillo (G)

Dipartimento di Ematologia e trapianto di midollo, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.

Francesca Patriarca (F)

Clinica Ematologica ed Unità Terapie Cellulari, Azienda Sanitaria Universitaria Friuli Centrale, Dipartimento di Area Medica, Università di Udine, Udine, Italy.

Giulia Zacchi (G)

SCDU Ematologia AO SS Antonio e Biagio e Cesare Arrigo ed Università del Piemonte Orientale, Alessandria, Italy.

Mauro Krampera (M)

UOC di Ematologia e Centro Trapianto di Midollo Osseo - Azienda Ospedaliera Universitaria Integrata Verona Policlinico G.B. Rossi, Verona, Italy.

Martina Pennisi (M)

Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.

Eugenio Galli (E)

Department of Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.

Maurizio Martelli (M)

Hematology Section, Department of Translational and Precision Medicine, "Sapienza" University of Rome, Roma, Italy.

Andrés J M Ferreri (AJM)

Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy.

Silvia Ferrari (S)

Department of Oncology and Hematology, Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.

Riccardo Saccardi (R)

SOD Terapie Cellulari e Medicina Trasfusionale, Azienda Ospedaliero-Universitaria Careggi, Firenze, Italy.

Anisa Bermema (A)

Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.

Anna Guidetti (A)

Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
Chair of Hematology, University of Milano, Milano, Italy.

Rosalba Miceli (R)

Unit of Biostatistics for Clinical Research, Department of Data Science, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.

Pier Luigi Zinzani (PL)

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy.
Dipartimento di Scienze Mediche e Chirurgiche, Università di Bologna, Bologna, Italy.

Paolo Corradini (P)

Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
Chair of Hematology, University of Milano, Milano, Italy.

Classifications MeSH