A Fibrin-Thrombin Based In Vitro Perfusion System to Study Flow-Related Prosthetic Heart Valves Thrombosis.

Fibrin clot Hemodynamics Prosthetic heart valve Recirculating flow Thrombosis

Journal

Annals of biomedical engineering
ISSN: 1573-9686
Titre abrégé: Ann Biomed Eng
Pays: United States
ID NLM: 0361512

Informations de publication

Date de publication:
08 Mar 2024
Historique:
received: 02 11 2023
accepted: 20 02 2024
medline: 9 3 2024
pubmed: 9 3 2024
entrez: 8 3 2024
Statut: aheadofprint

Résumé

Prosthetic heart valve (PHV) replacement has increased the survival rate and quality of life for heart valve-diseased patients. However, PHV thrombosis remains a critical problem associated with these procedures. To better understand the PHV flow-related thrombosis problem, appropriate experimental models need to be developed. In this study, we present an in vitro fibrin clot model that mimics clot accumulation in PHVs under relevant hydrodynamic conditions while allowing real-time imaging. We created 3D-printed mechanical aortic valve models that were inserted into a transparent glass aorta model and connected to a system that simulates human aortic flow pulse and pressures. Thrombin was gradually injected into a circulating fibrinogen solution to induce fibrin clot formation, and clot accumulation was quantified via image analysis. The results of valves positioned in a normal versus a tilted configuration showed that clot accumulation correlated with the local flow features and was mainly present in areas of low shear and high residence time, where recirculating flows are dominant, as supported by computational fluid dynamic simulations. Overall, our work suggests that the developed method may provide data on flow-related clot accumulation in PHVs and may contribute to exploring new approaches and valve designs to reduce valve thrombosis.

Identifiants

pubmed: 38459196
doi: 10.1007/s10439-024-03480-6
pii: 10.1007/s10439-024-03480-6
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Israel Innovation Authority
ID : 72268

Informations de copyright

© 2024. The Author(s).

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Auteurs

Yevgeniy Kreinin (Y)

Department of Biomedical Engineering, Technion-IIT, 3200003, Haifa, Israel.

Yahel Talmon (Y)

Department of Biomedical Engineering, Technion-IIT, 3200003, Haifa, Israel.

Moran Levi (M)

Department of Biomedical Engineering, Technion-IIT, 3200003, Haifa, Israel.

Maria Khoury (M)

Department of Biomedical Engineering, Technion-IIT, 3200003, Haifa, Israel.

Itay Or (I)

Department of Cardiac Surgery, Rambam Health Care Campus, 3109601, Haifa, Israel.

Mahli Raad (M)

Department of Cardiac Surgery, Rambam Health Care Campus, 3109601, Haifa, Israel.

Gil Bolotin (G)

Department of Cardiac Surgery, Rambam Health Care Campus, 3109601, Haifa, Israel.
The Ruth Bruce Rappaport Faculty of Medicine, Technion-IIT, 3525433, Haifa, Israel.

Josué Sznitman (J)

Department of Biomedical Engineering, Technion-IIT, 3200003, Haifa, Israel.

Netanel Korin (N)

Department of Biomedical Engineering, Technion-IIT, 3200003, Haifa, Israel. korin@bm.technion.ac.il.

Classifications MeSH