Vitamin D and risk of developing type 2 diabetes in the SUN project: a prospective cohort study.
Predicted vitamin D
Prospective cohort
SUN project
Type 2 diabetes
Journal
Journal of endocrinological investigation
ISSN: 1720-8386
Titre abrégé: J Endocrinol Invest
Pays: Italy
ID NLM: 7806594
Informations de publication
Date de publication:
08 Mar 2024
08 Mar 2024
Historique:
received:
13
10
2023
accepted:
28
01
2024
medline:
9
3
2024
pubmed:
9
3
2024
entrez:
8
3
2024
Statut:
aheadofprint
Résumé
Vitamin D deficiency has been associated with multiple chronic diseases, including metabolic disorders such as insulin resistance and type 2 diabetes (T2D). The aim of the study was to analyze the association between validated predicted serum vitamin D status and the risk of developing T2D in a large prospective cohort based on a Mediterranean population. The SUN project is a prospective and dynamic Spanish cohort that gathers university graduates who have answered lifestyle questionnaires, including a validated Food Frequency Questionnaire. The association between predicted serum vitamin D and the risk of T2D was assessed through Cox regression models according to quartiles (Q) of predicted vitamin D at baseline. The models were adjusted for potential confounders and sensitivity analyses were performed to ensure the robustness of our findings. Our study included a total of 18,594 participants and after a total follow-up of 238,078 person-years (median follow-up of 13.5 years), 209 individuals were diagnosed with incident T2D. We found a significant inverse association between predicted levels of serum vitamin D and the risk of developing T2D, after adjusting for potential confounders and performing different sensitivity analyses (hazard ratio Q4 vs. Q1: 0.48, 95% CI 0.26-0.88; p for trend = 0.032). The outcomes suggest that higher levels of vitamin D at baseline may be associated with a reduced risk of developing T2D.
Identifiants
pubmed: 38459212
doi: 10.1007/s40618-024-02324-3
pii: 10.1007/s40618-024-02324-3
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Regional Development Fund
ID : RD 06/0045
Organisme : Ministerio de Ciencia e Innovación
ID : PI10/02293
Organisme : Ministerio de Ciencia e Innovación
ID : PI13/00615
Organisme : Ministerio de Ciencia e Innovación
ID : PI14/01668
Organisme : Ministerio de Ciencia e Innovación
ID : PI17/01795
Organisme : Ministerio de Ciencia e Innovación
ID : PI20/00564
Organisme : Ministerio de Ciencia e Innovación
ID : PI10/02658
Organisme : Ministerio de Ciencia e Innovación
ID : PI14/01798
Organisme : Ministerio de Ciencia e Innovación
ID : PI14/01764
Organisme : Ministerio de Ciencia e Innovación
ID : G03/140
Organisme : Gobierno de Navarra
ID : 27/2011
Organisme : Gobierno de Navarra
ID : 45/2011
Organisme : Gobierno de Navarra
ID : 122/2014
Organisme : Plan Nacional sobre Drogas
ID : 2020/021
Informations de copyright
© 2024. The Author(s).
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