RIP140 regulates transcription factor HES1 oscillatory expression and mitogenic activity in colon cancer cells.
HES1
Notch pathway
RIP140
colorectal cancer
Journal
Molecular oncology
ISSN: 1878-0261
Titre abrégé: Mol Oncol
Pays: United States
ID NLM: 101308230
Informations de publication
Date de publication:
08 Mar 2024
08 Mar 2024
Historique:
revised:
17
01
2024
received:
28
06
2023
accepted:
23
02
2024
medline:
9
3
2024
pubmed:
9
3
2024
entrez:
9
3
2024
Statut:
aheadofprint
Résumé
The transcription factor receptor-interacting protein 140 (RIP140) regulates intestinal homeostasis and tumorigenesis through Wnt signaling. In this study, we investigated its effect on the Notch/HES1 signaling pathway. In colorectal cancer (CRC) cell lines, RIP140 positively regulated HES1 gene expression at the transcriptional level via a recombining binding protein suppressor of hairless (RBPJ)/neurogenic locus notch homolog protein 1 (NICD)-mediated mechanism. In support of these in vitro data, RIP140 and HES1 expression significantly correlated in mouse intestine and in a cohort of CRC samples, thus supporting the positive regulation of HES1 gene expression by RIP140. Interestingly, when the Notch pathway is fully activated, RIP140 exerted a strong inhibition of HES1 gene transcription controlled by the level of HES1 itself. Moreover, RIP140 directly interacts with HES1 and reversed its mitogenic activity in human CRC cells. In line with this observation, HES1 levels were associated with a better patient survival only when tumors expressed high levels of RIP140. Our data identify RIP140 as a key regulator of the Notch/HES1 signaling pathway, with a dual effect on HES1 gene expression at the transcriptional level and a strong impact on colon cancer cell proliferation.
Identifiants
pubmed: 38459621
doi: 10.1002/1878-0261.13626
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fondation pour la Recherche Médicale
ID : DEQ20170336713
Organisme : Institut National de la Santé et de la Recherche Médicale
Organisme : Institut régional du Cancer de Montpellier (ICM)
Organisme : Erasmus Mundus AVEMPACE III
Organisme : Université de Montpellier
Organisme : SIRIC Montpellier Cancer
ID : INCa-DGOS-Inserm_12553
Organisme : Ligue Contre le Cancer
ID : RAB17007FFA
Informations de copyright
© 2024 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
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