Ammonia is associated with liver-related complications and predicts mortality in acute-on-chronic liver failure patients.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
09 Mar 2024
09 Mar 2024
Historique:
received:
30
10
2023
accepted:
06
03
2024
medline:
10
3
2024
pubmed:
10
3
2024
entrez:
9
3
2024
Statut:
epublish
Résumé
The relationship between ammonia and liver-related complications (LRCs) in acute-on-chronic liver failure (ACLF) patients is not clearly established. This study aimed to evaluate the association between ammonia levels and LRCs in patients with ACLF. The study also evaluated the ability of ammonia in predicting mortality and progression of LRCs. The study prospectively recruited ACLF patients based on the APASL definition from the ACLF Research Consortium (AARC) from 2009 to 2019. LRCs were a composite endpoint of bacterial infection, overt hepatic encephalopathy (HE), and ascites. A total of 3871 cases were screened. Of these, 701 ACLF patients were enrolled. Patients with LRCs had significantly higher ammonia levels than those without. Ammonia was significantly higher in patients with overt HE and ascites, but not in those with bacterial infection. Multivariate analysis found that ammonia was associated with LRCs. Additionally, baseline arterial ammonia was an independent predictor of 30-day mortality, but it was not associated with the development of new LRCs within 30 days. In summary, baseline arterial ammonia levels are associated with 30-day mortality and LRCs, mainly overt HE and ascites in ACLF patients.
Identifiants
pubmed: 38461166
doi: 10.1038/s41598-024-56401-x
pii: 10.1038/s41598-024-56401-x
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5796Subventions
Organisme : Ratchadaphiseksomphot Endowment Fund of Center of Excellence in Hepatic Fibrosis and Cirrhosis, Chulalongkorn University
ID : GCE 3300170037
Informations de copyright
© 2024. The Author(s).
Références
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