Identification of the growth cone as a probe and driver of neuronal migration in the injured brain.

Journal

Nature communications

ISSN: 2041-1723

Titre abrégé: Nat Commun

Pays: England

ID NLM: 101528555

Informations de publication

Date de publication:
09 Mar 2024

Historique:

received: 20 11 2022

accepted: 01 02 2024

medline: 10 3 2024

pubmed: 10 3 2024

entrez: 9 3 2024

Statut: epublish

Résumé

Axonal growth cones mediate axonal guidance and growth regulation. We show that migrating neurons in mice possess a growth cone at the tip of their leading process, similar to that of axons, in terms of the cytoskeletal dynamics and functional responsivity through protein tyrosine phosphatase receptor type sigma (PTPσ). Migrating-neuron growth cones respond to chondroitin sulfate (CS) through PTPσ and collapse, which leads to inhibition of neuronal migration. In the presence of CS, the growth cones can revert to their extended morphology when their leading filopodia interact with heparan sulfate (HS), thus re-enabling neuronal migration. Implantation of an HS-containing biomaterial in the CS-rich injured cortex promotes the extension of the growth cone and improve the migration and regeneration of neurons, thereby enabling functional recovery. Thus, the growth cone of migrating neurons is responsive to extracellular environments and acts as a primary regulator of neuronal migration.

Identifiants

DOI: 10.1038/s41467-024-45825-8 PMID: 38461182

pubmed: 38461182

doi: 10.1038/s41467-024-45825-8

pii: 10.1038/s41467-024-45825-8

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

1877

Subventions

Organisme : Japan Agency for Medical Research and Development (AMED)

ID : 23gm1210007, 21bm0704033h0003

Informations de copyright

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