Alterations of Functional Connectivity Dynamics in Affective and Psychotic Disorders.

Journal

Biological psychiatry. Cognitive neuroscience and neuroimaging
ISSN: 2451-9030
Titre abrégé: Biol Psychiatry Cogn Neurosci Neuroimaging
Pays: United States
ID NLM: 101671285

Informations de publication

Date de publication:
08 Mar 2024
Historique:
received: 30 11 2023
revised: 23 01 2024
accepted: 15 02 2024
medline: 11 3 2024
pubmed: 11 3 2024
entrez: 10 3 2024
Statut: aheadofprint

Résumé

Psychosis and depression patients exhibit widespread neurobiological abnormalities. The analysis of dynamic functional connectivity (dFC), allows for the detection of changes in complex brain activity patterns, providing insights into common and unique processes underlying these disorders. In the present study, we report the analysis of dFC in a large patient sample including 127 clinical high-risk patients (CHR), 142 recent-onset psychosis (ROP) patients, 134 recent-onset depression (ROD) patients, and 256 healthy controls (HC). A sliding window-based technique was used to calculate the time-dependent FC in resting-state MRI data, followed by clustering to reveal recurrent FC states in each diagnostic group. We identified five unique FC states, which could be identified in all groups with high consistency (r Our findings indicate diagnosis-specific alterations of dFC and underline the potential of dynamic analysis to characterize disorders such as depression, psychosis and clinical risk states.

Sections du résumé

BACKGROUND BACKGROUND
Psychosis and depression patients exhibit widespread neurobiological abnormalities. The analysis of dynamic functional connectivity (dFC), allows for the detection of changes in complex brain activity patterns, providing insights into common and unique processes underlying these disorders.
METHODS METHODS
In the present study, we report the analysis of dFC in a large patient sample including 127 clinical high-risk patients (CHR), 142 recent-onset psychosis (ROP) patients, 134 recent-onset depression (ROD) patients, and 256 healthy controls (HC). A sliding window-based technique was used to calculate the time-dependent FC in resting-state MRI data, followed by clustering to reveal recurrent FC states in each diagnostic group.
RESULTS RESULTS
We identified five unique FC states, which could be identified in all groups with high consistency (r
CONCLUSIONS CONCLUSIONS
Our findings indicate diagnosis-specific alterations of dFC and underline the potential of dynamic analysis to characterize disorders such as depression, psychosis and clinical risk states.

Identifiants

DOI: 10.1016/j.bpsc.2024.02.013 PMID: 38461964
pubmed: 38461964
pii: S2451-9022(24)00065-X
doi: 10.1016/j.bpsc.2024.02.013
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Investigateurs

Linda Betz (L)
Anne Erkens (A)
Eva Gussmann (E)
Shalaila Haas (S)
Alkomiet Hasan (A)
Claudius Hoff (C)
Ifrah Khanyaree (I)
Aylin Melo (A)
Susanna Muckenhuber-Sternbauer (S)
Janis Köhler (J)
Ömer Öztürk (Ö)
Nora Penzel (N)
David Popovic (D)
Adrian Rangnick (A)
Sebastian von Saldern (S)
Rachele Sanfelici (R)
Moritz Spangemacher (M)
Ana Tupac (A)
Maria Fernanda Urquijo (MF)
Johanna Weiske (J)
Antonia Wosgien (A)
Karsten Blume (K)
Dominika Gebhardt (D)
Nathalie Kaiser (N)
Ruth Milz (R)
Alexandra Nikolaides (A)
Mauro Seves (M)
Silke Vent (S)
Martina Wassen (M)
Christina Andreou (C)
Laura Egloff (L)
Fabienne Harrisberger (F)
Claudia Lenz (C)
Letizia Leanza (L)
Amatya Mackintosh (A)
Renata Smieskova (R)
Erich Studerus (E)
Anna Walter (A)
Sonja Widmayer (S)
Chris Day (C)
Mariam Iqbal (M)
Mirabel Pelton (M)
Pavan Mallikarjun (P)
Alexandra Stainton (A)
Ashleigh Lin (A)
Alexander Denissoff (A)
Anu Ellilä (A)
Tiina From (T)
Markus Heinimaa (M)
Tuula Ilonen (T)
Päivi Jalo (P)
Heikki Laurikainen (H)
Antti Luutonen (A)
Akseli Mäkela (A)
Janina Paju (J)
Henri Pesonen (H)
Reetta-Liina Säilä (RL)
Anna Toivonen (A)
Otto Turtonen (O)
Ana Beatriz Solana (AB)
Manuela Abraham (M)
Nicolas Hehn (N)
Timo Schirmer (T)
Carlo Altamura (C)
Marika Belleri (M)
Francesca Bottinelli (F)
Adele Ferro (A)
Marta Re (M)
Emiliano Monzani (E)
Maurizio Sberna (M)
Armando D'Agostino (A)
Lorenzo Del Fabro (L)
Giampaolo Perna (G)
Maria Nobile (M)
Alessandra Alciati (A)
Matteo Balestrieri (M)
Carolina Bonivento (C)
Giuseppe Cabras (G)
Franco Fabbro (F)
Marco Garzitto (M)
Sara Piccin (S)

Informations de copyright

Copyright © 2024. Published by Elsevier Inc.

Auteurs

Linnea Hoheisel (L)

Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Forschungszentrum Jülich, Jülich, Germany; Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.

Lana Kambeitz-Ilankovic (L)

Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany; Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany.

Julian Wenzel (J)

Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.

Shalaila S Haas (SS)

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Linda A Antonucci (LA)

Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.

Anne Ruef (A)

Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany.

Nora Penzel (N)

Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Frauke Schultze-Lutter (F)

Department of Psychiatry and Psychotherapy, University of Düsseldorf, Düsseldorf, Germany; University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Department of Psychology and Mental Health, Faculty of Psychology, Airlangga University, Surabaya, Indonesia.

Theresa Lichtenstein (T)

Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.

Marlene Rosen (M)

Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.

Dominic B Dwyer (DB)

Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia; Orygen, Parkville, VIC, Australia.

Raimo K R Salokangas (RKR)

Department of Psychiatry, University of Turku, Turku, Finland.

Rebekka Lencer (R)

Institute for Translational Psychiatry, University of Münster, Münster, Germany; Department of Psychiatry and Psychotherapy, Lübeck University, Lübeck, Germany.

Paolo Brambilla (P)

Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; Department of Neurosciences and Mental Health, IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Stephan Borgwardt (S)

Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany.

Stephen J Wood (SJ)

Institute for Mental Health, University of Birmingham, Birmingham, United Kingdom; Orygen, Parkville, Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, Melbourne, Victoria, Australia.

Rachel Upthegrove (R)

Institute for Mental Health, University of Birmingham, Birmingham, United Kingdom; Centre for Human Brain Health, University of Birmingham, Birmingham, United Kingdom; Birmingham Early Interventions Service, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, United Kingdom.

Alessandro Bertolino (A)

Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy.

Stephan Ruhrmann (S)

Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.

Eva Meisenzahl (E)

Department of Psychiatry and Psychotherapy, University of Düsseldorf, Düsseldorf, Germany.

Nikolaos Koutsouleris (N)

Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany.

Gereon R Fink (GR)

Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Forschungszentrum Jülich, Jülich, Germany; Department of Neurology, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.

Silvia Daun (S)

Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Forschungszentrum Jülich, Jülich, Germany; Institute of Zoology, University of Cologne, Cologne, Germany.

Joseph Kambeitz (J)

Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Forschungszentrum Jülich, Jülich, Germany; Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany. Electronic address: Joseph.Kambeitz@uk-koeln.de.

Classifications MeSH