Management of CRSwNP in Latin America: A multidisciplinary consensus from an expert working group.

Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory condition of the nasal and paranasal tissues, characterized by the presence of bilateral nasal polyps. While etiology and pathogenetic mechanisms are heterogeneous and complex, in most patients, disease is mediated predominantly through type 2 inflammatory processes. Clinical management is challenging, and a multidisciplinary approach is preferred. Principal treatment approaches are the use of local/systemic corticosteroids and sinonasal surgery, although outcomes can be unsatisfactory. Recent availability of biological therapies targeting underlying inflammatory processes can offer effective treatment options in uncontrolled disease. Specialist guidelines greatly assist clinical decision-making, although as these are chiefly written from a global/international perspective, they may not wholly accommodate disease patterns and clinical practice at a regional level. An expert panel of specialists from Latin America was convened to develop regional guidance on the management of CRSwNP through a consensus approach. The present article presents the chief observations and recommendations which can provide guidance for clinicians in the Latin American region.

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© 2024 Published by Elsevier Inc. on behalf of World Allergy Organization.

Déclaration de conflit d'intérêts

JFM has acted as a speaker, advisory board member, and/or investigator for Sanofi, AstraZeneca, Novartis, Inmunito, Uriach, GSK, Menarini and MSD. DB has attended advisory board and received sponsorship from Sanofi. AS has acted as an advisor for Sanofi. WA-L, MAJC, JO, RR and RSR have no direct or indirect conflict of interests to declare.