Investigating the Association Between Extended Participation in Collision Sports and Fluid Biomarkers Among Masters Athletes.

GFAP NfL UCH-L1 concussion inflammation neurodegeneration p-tau-181 tau telomere

Journal

Neurotrauma reports
ISSN: 2689-288X
Titre abrégé: Neurotrauma Rep
Pays: United States
ID NLM: 101773091

Informations de publication

Date de publication:
2024
Historique:
medline: 11 3 2024
pubmed: 11 3 2024
entrez: 11 3 2024
Statut: epublish

Résumé

Traumatic brain injuries (TBIs) and concussions are prevalent in collision sports, and there is evidence that levels of exposure to such sports may increase the risk of neurological abnormalities. Elevated levels of fluid-based biomarkers have been observed after concussions or among athletes with a history of participating in collision sports, and certain biomarkers exhibit sensitivity toward neurodegeneration. This study investigated a cohort of 28 male amateur athletes competing in "Masters" competitions for persons >35 years of age. The primary objective of this study was to compare the levels of blood and saliva biomarkers associated with brain injury, inflammation, aging, and neurodegeneration between athletes with an extensive history of collision sport participation (i.e., median = 27 years; interquartile range = 18-44, minimum = 8) and those with no history. Plasma proteins associated with neural damage and neurodegeneration were measured using Simoa

Identifiants

pubmed: 38463419
doi: 10.1089/neur.2023.0086
pii: 10.1089/neur.2023.0086
pmc: PMC10923547
doi:

Types de publication

Journal Article

Langues

eng

Pagination

74-80

Informations de copyright

© Lauren P. Giesler et al., 2024; Published by Mary Ann Liebert, Inc.

Déclaration de conflit d'intérêts

No competing financial interests exist.

Auteurs

Lauren P Giesler (LP)

Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.

William T O'Brien (WT)

Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.

Georgia F Symons (GF)

Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.

Sabrina Salberg (S)

Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.

Gershon Spitz (G)

Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
Turner Institute for Brain and Mental Health, Monash University, Melbourne, Victoria, Australia.

Robb Wesselingh (R)

Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
Department of Neurology, Alfred Hospital, Melbourne, Victoria, Australia.

Terence J O'Brien (TJ)

Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
Department of Neurology, Alfred Hospital, Melbourne, Victoria, Australia.
Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.

Richelle Mychasiuk (R)

Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.

Sandy R Shultz (SR)

Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
Department of Neurology, Alfred Hospital, Melbourne, Victoria, Australia.
Health Sciences, Vancouver Island University, Nanaimo, British Columbia, Canada.

Stuart J McDonald (SJ)

Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
Department of Neurology, Alfred Hospital, Melbourne, Victoria, Australia.

Classifications MeSH