Strategies for Inducing and Validating Zinc Deficiency and Zinc Repletion.
Dietary approach
Mouse Model
Zinc Deficiency
Zinc Repletion
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
10 Mar 2024
10 Mar 2024
Historique:
pubmed:
11
3
2024
medline:
11
3
2024
entrez:
11
3
2024
Statut:
epublish
Résumé
Given the growing interest in the role of zinc in the onset and progression of diseases, there is a crucial demand for reliable methods to modulate zinc homeostasis. Using a dietary approach, we provide validated strategies to alter whole-body zinc in mice, applicable across species. For confirmation of zinc status, animal growth rates as well as plasma and urine zinc levels were evaluated. The accessible and cost-effective methodology outlined will increase scientific rigor, ensuring reproducibility in studies exploring the impact of zinc deficiency and repletion on the onset and progression of diseases.
Identifiants
pubmed: 38463970
doi: 10.1101/2024.02.28.582542
pmc: PMC10925336
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK133698
Pays : United States
Organisme : NIDDK NIH HHS
ID : R21 DK119879
Pays : United States
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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