Evolution of pH-sensitive transcription termination during adaptation to repeated long-term starvation.

adaptation alkaline stress changing environment gene regulation phenotypic plasticity

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
01 Mar 2024
Historique:
pubmed: 11 3 2024
medline: 11 3 2024
entrez: 11 3 2024
Statut: epublish

Résumé

Fluctuating environments that consist of regular cycles of co-occurring stress are a common challenge faced by cellular populations. For a population to thrive in constantly changing conditions, an ability to coordinate a rapid cellular response is essential. Here, we identify a mutation conferring an arginine-to-histidine (Arg to His) substitution in the transcription terminator Rho. The

Identifiants

pubmed: 38464051
doi: 10.1101/2024.03.01.582989
pmc: PMC10925284
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM150625
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK058404
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY008126
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020593
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA068485
Pays : United States
Organisme : NIH HHS
ID : S10 OD018075
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK059637
Pays : United States

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Auteurs

Sarah B Worthan (SB)

Department of Biological Sciences, Vanderbilt University, Nashville, TN.
Evolutionary Studies Initiative, Vanderbilt University, Nashville, TN.
Vanderbilt Institute for Infection, Immunology and Inflammation, Nashville, TN.

Robert D P McCarthy (RDP)

Department of Biological Sciences, Vanderbilt University, Nashville, TN.

Mildred Delaleau (M)

Centre de Biophysique Moléculaire, CNRS UPR4301, affiliated with Université d'Orléans, rue Charles Sadron, 45071 Orléans cedex 2, France.

Ryan Stikeleather (R)

Biodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, AZ.

Benjamin P Bratton (BP)

Evolutionary Studies Initiative, Vanderbilt University, Nashville, TN.
Vanderbilt Institute for Infection, Immunology and Inflammation, Nashville, TN.
Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN.
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN.

Marc Boudvillain (M)

Centre de Biophysique Moléculaire, CNRS UPR4301, affiliated with Université d'Orléans, rue Charles Sadron, 45071 Orléans cedex 2, France.

Megan G Behringer (MG)

Department of Biological Sciences, Vanderbilt University, Nashville, TN.
Evolutionary Studies Initiative, Vanderbilt University, Nashville, TN.
Vanderbilt Institute for Infection, Immunology and Inflammation, Nashville, TN.
Biodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, AZ.

Classifications MeSH