ScISOr-ATAC reveals convergent and divergent splicing and chromatin specificities between matched cell types across cortical regions, evolution, and in Alzheimer's Disease.
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
28 Feb 2024
28 Feb 2024
Historique:
pubmed:
11
3
2024
medline:
11
3
2024
entrez:
11
3
2024
Statut:
epublish
Résumé
Multimodal measurements have become widespread in genomics, however measuring open chromatin accessibility and splicing simultaneously in frozen brain tissues remains unconquered. Hence, we devised Single-Cell-ISOform-RNA sequencing coupled with the Assay-for-Transposase-Accessible-Chromatin (ScISOr-ATAC). We utilized ScISOr-ATAC to assess whether chromatin and splicing alterations in the brain convergently affect the same cell types or divergently different ones. We applied ScISOr-ATAC to three major conditions: comparing (i) the Rhesus macaque (
Identifiants
pubmed: 38464236
doi: 10.1101/2024.02.24.581897
pmc: PMC10925193
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM135247
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA053625
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH134391
Pays : United States
Organisme : NIMH NIH HHS
ID : RF1 MH121267
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH125956
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS123562
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA058527
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH130197
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH125737
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA039080
Pays : United States
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