Fluoride-related changes in the fetal cord blood proteome; a pilot study.
Journal
Research square
Titre abrégé: Res Sq
Pays: United States
ID NLM: 101768035
Informations de publication
Date de publication:
01 Mar 2024
01 Mar 2024
Historique:
pubmed:
11
3
2024
medline:
11
3
2024
entrez:
11
3
2024
Statut:
epublish
Résumé
Fluoride exposure during pregnancy has been associated with various effects on offspring, including changes in behavior and IQ. To provide clues to possible mechanisms by which fluoride affects human fetal development, we completed proteomic analyses of cord blood serum collected from second-trimester pregnant women residing in Northern California with either high or low fluoride exposure, as identified by maternal serum fluoride concentrations. To identify changes in cord blood proteins associated with maternal serum fluoride concentration in pregnant women living in Northern California. The proteomes of 19 archived second-trimester cord blood samples representing highest and lowest serum fluoride concentrations from a cohort of 48 women living in Northern California, previously analyzed for serum, urine and amniotic fluoride concentrations, were characterized by mass spectrometry. Proteins highly correlated to maternal serum fluoride concentrations were identified, and further compared in a group of samples from women with the highest serum fluoride to the group with the lowest maternal serum fluoride concentrations. Nine cord blood proteins were significantly correlated with maternal serum fluoride concentrations. Six of these proteins, including apolipoprotein B-100, delta homolog 1, coagulation factor X, mimecan, plasma kallikrein, and vasorin, were significantly decreased in the cord blood from women with the highest serum fluoride levels. Changes in the relative amounts of second trimester cord blood proteins included proteins associated with the development of the fetal hematopoetic system.
Sections du résumé
Background
UNASSIGNED
Fluoride exposure during pregnancy has been associated with various effects on offspring, including changes in behavior and IQ. To provide clues to possible mechanisms by which fluoride affects human fetal development, we completed proteomic analyses of cord blood serum collected from second-trimester pregnant women residing in Northern California with either high or low fluoride exposure, as identified by maternal serum fluoride concentrations.
Objective
UNASSIGNED
To identify changes in cord blood proteins associated with maternal serum fluoride concentration in pregnant women living in Northern California.
Methods
UNASSIGNED
The proteomes of 19 archived second-trimester cord blood samples representing highest and lowest serum fluoride concentrations from a cohort of 48 women living in Northern California, previously analyzed for serum, urine and amniotic fluoride concentrations, were characterized by mass spectrometry. Proteins highly correlated to maternal serum fluoride concentrations were identified, and further compared in a group of samples from women with the highest serum fluoride to the group with the lowest maternal serum fluoride concentrations.
Results
UNASSIGNED
Nine cord blood proteins were significantly correlated with maternal serum fluoride concentrations. Six of these proteins, including apolipoprotein B-100, delta homolog 1, coagulation factor X, mimecan, plasma kallikrein, and vasorin, were significantly decreased in the cord blood from women with the highest serum fluoride levels.
Conclusion
UNASSIGNED
Changes in the relative amounts of second trimester cord blood proteins included proteins associated with the development of the fetal hematopoetic system.
Identifiants
pubmed: 38464284
doi: 10.21203/rs.3.rs-3995767/v1
pmc: PMC10925477
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIEHS NIH HHS
ID : P01 ES022841
Pays : United States
Déclaration de conflit d'intérêts
Competing interests The authors declare that they have no competing interests.
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