MUTATIONEXPLORER- A WEBSERVER FOR MUTATION OF PROTEINS AND 3D VISUALIZATION OF ENERGETIC IMPACTS.
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
28 Feb 2024
28 Feb 2024
Historique:
pubmed:
11
3
2024
medline:
11
3
2024
entrez:
11
3
2024
Statut:
epublish
Résumé
The possible effects of mutations on stability and function of a protein can only be understood in the context of protein 3D structure. The MutationExplorer webserver maps sequence changes onto protein structures and allows users to study variation by inputting sequence changes. As the user enters variants, the 3D model evolves, and estimated changes in energy are highlighted. In addition to a basic per-residue input format, MutationExplorer can also upload an entire replacement sequence. Previously the purview of desktop applications, such an upload can back-mutate PDB structures to wildtype sequence in a single step. Another supported variation source is human single nucelotide polymorphisms (SNPs), genomic coordinates input in VCF format.
Identifiants
pubmed: 38464310
doi: 10.1101/2023.03.23.533926
pmc: PMC10925206
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIDA NIH HHS
ID : R01 DA046138
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG068623
Pays : United States
Organisme : NIH HHS
ID : S10 OD032234
Pays : United States
Organisme : NIH HHS
ID : S10 OD020154
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL122010
Pays : United States
Organisme : NLM NIH HHS
ID : R01 LM013434
Pays : United States
Organisme : NIH HHS
ID : S10 OD016216
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA227833
Pays : United States
Déclaration de conflit d'intérêts
Declarations The authors declare no conflict of interest.
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