Circulating Tumor Reactive KIR+CD8+ T cells Suppress Anti-Tumor Immunity in Patients with Melanoma.


Journal

Research square
Titre abrégé: Res Sq
Pays: United States
ID NLM: 101768035

Informations de publication

Date de publication:
28 Feb 2024
Historique:
pubmed: 11 3 2024
medline: 11 3 2024
entrez: 11 3 2024
Statut: epublish

Résumé

Effective anti-tumor immunity is largely driven by cytotoxic CD8

Identifiants

pubmed: 38464315
doi: 10.21203/rs.3.rs-3956671/v1
pmc: PMC10925449
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NLM NIH HHS
ID : T15 LM007056
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA233414
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA227473
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA269286
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI039671
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA121974
Pays : United States
Organisme : NIH HHS
ID : S10 OD030363
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016359
Pays : United States

Déclaration de conflit d'intérêts

DAH has received research funding from Bristol-Myers Squibb, Novartis, Sanofi, and Genentech. He has been a consultant for Bayer Pharmaceuticals, Repertoire Inc, Bristol Myers Squibb, Compass Therapeutics, EMD Serono, Genentech, Juno therapeutics, Novartis Pharmaceuticals, Proclara Biosciences, Sage Therapeutics, and Sanofi Genzyme. HMK has received institutional research grants from Bristol Myers Squibb, Merck, and Apexigen and financial support from Bristol Myers Squibb, Iovance, Chemocentryx, Signatero, Gigagen, GI Reviewers, Pliant Therapeutics, Esai, Wherewolf, and Invox. CN, SH, AJC, JK, and FJO are employees and/or stockholders of Repertoire Immune Medicines. SH, FJO, and JK are employees of Repertoire Immune Medicines (Switzerland) AG, formerly Tepthera Ltd. All other authors report no competing interests.

Auteurs

Liliana Lucca (L)

Yale School of Medicine.

Wesley Lewis (W)

Yale University.

Jiping Wang (J)

Yale School of Public Health.

Catarina Nogeuira (C)

Repertoire Immune Medicines.

Sebastian Heer (S)

Repertoire Immune Medicines.

Giang Pham (G)

Yale School of Medicine.

Mina Kojima (M)

Department of Genetics, Yale University.

Wei Wei (W)

Yale School of Medicine.

Lilach Aizenbud (L)

Yale School of Medicine.

Antonietta Bacchiocchi (A)

Yale School of Medicine.

Lin Zhang (L)

Yale School of Medicine.

Joseph Walewski (J)

Yale School of Medicine.

Veronica Chiang (V)

Yale School of Medicine.

Kelly Olino (K)

Yale School of Medicine.

James Clune (J)

Yale School of Medicine.

Ruth Halaban (R)

Yale University School of Medicine.

Yuval Kluger (Y)

Yale University School of Medicine.

Anthony Coyle (A)

Repertoire Immune Medicines.

Jan Kisielow (J)

Repertoire Immune Medicine (Switzerland).

Franz-Josef Obermair (FJ)

Repertoire Immune Medicine (Switzerland).

Harriet Kluger (H)

Yale University School of Medicine.

Classifications MeSH