Dietary Magnesium Intake Is Inversely Associated With Ulcerative Colitis: A Case-Control Study.

case–control inflammatory bowel disease magnesium nutrition epidemiology ulcerative colitis

Journal

Crohn's & colitis 360
ISSN: 2631-827X
Titre abrégé: Crohns Colitis 360
Pays: England
ID NLM: 101752188

Informations de publication

Date de publication:
Jan 2024
Historique:
received: 19 08 2023
medline: 11 3 2024
pubmed: 11 3 2024
entrez: 11 3 2024
Statut: epublish

Résumé

Ulcerative colitis (UC) causes long-lasting inflammation and ulcers in the gut. Limited observational data are available linking dietary magnesium intake and UC. In the present study, we aimed to investigate the association between dietary magnesium intake and UC in adults. The current population-based case-control study was performed on 109 UC patients and 218 age (±2 years) and sex-matched controls. The diagnosis of UC was made according to the standard criteria by a gastroenterology specialist. Dietary intakes were assessed using a validated self-administrated 106-item dish-based Food Frequency Questionnaire (FFQ). We also used a pretested questionnaire to collect data on potential confounders. Individuals in the top tertile of magnesium intake were less likely to have UC compared with those in the bottom tertile. A significant inverse relationship was found between dietary magnesium intake and UC (odds ratio [OR]: 0.32, 95% confidence interval [CI]: 0.18-0.59) in the crude model. This relationship was also observed when we took several potential confounding into account (OR: 0.30, 95% CI: 0.14-0.68). Adherence to a magnesium-rich diet may have a role in preventing UC. However, further studies are needed to confirm our findings.

Sections du résumé

Background UNASSIGNED
Ulcerative colitis (UC) causes long-lasting inflammation and ulcers in the gut. Limited observational data are available linking dietary magnesium intake and UC. In the present study, we aimed to investigate the association between dietary magnesium intake and UC in adults.
Methods UNASSIGNED
The current population-based case-control study was performed on 109 UC patients and 218 age (±2 years) and sex-matched controls. The diagnosis of UC was made according to the standard criteria by a gastroenterology specialist. Dietary intakes were assessed using a validated self-administrated 106-item dish-based Food Frequency Questionnaire (FFQ). We also used a pretested questionnaire to collect data on potential confounders.
Results UNASSIGNED
Individuals in the top tertile of magnesium intake were less likely to have UC compared with those in the bottom tertile. A significant inverse relationship was found between dietary magnesium intake and UC (odds ratio [OR]: 0.32, 95% confidence interval [CI]: 0.18-0.59) in the crude model. This relationship was also observed when we took several potential confounding into account (OR: 0.30, 95% CI: 0.14-0.68).
Conclusions UNASSIGNED
Adherence to a magnesium-rich diet may have a role in preventing UC. However, further studies are needed to confirm our findings.

Identifiants

DOI: 10.1093/crocol/otae009 PMID: 38464345 PMC: PMC10923208
pubmed: 38464345
doi: 10.1093/crocol/otae009
pii: otae009
pmc: PMC10923208
doi:

Types de publication

Journal Article

Langues

eng

Pagination

otae009

Informations de copyright

© The Author(s) 2024. Published by Oxford University Press on behalf of Crohn's & Colitis Foundation.

Déclaration de conflit d'intérêts

None declared.

Auteurs

Omid Sadeghi (O)

Nutrition and Food Security Research Center, Department of Community Nutrition, Student Research Committee, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
ORCID: 0000-0002-1029-1652

Zeinab Khademi (Z)

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
ORCID: 0000-0001-8145-3172

Parvane Saneei (P)

Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

Ammar Hassanzadeh-Keshteli (A)

Department of Medicine, University of Alberta, Edmonton, Canada.
Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Hamed Daghaghzadeh (H)

Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Hamid Tavakkoli (H)

Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Peyman Adibi (P)

Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Ahmad Esmaillzadeh (A)

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Classifications MeSH