Multifocal Desmoid-Type Fibromatosis: Case Series and Potential Relationship to Neuronal Spread.
aggressive fibromatosis
beta-catenin
ctnnb1
desmoid tumor
msh6
neuromuscular choristoma
oncology
orthopedic oncology
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Feb 2024
Feb 2024
Historique:
accepted:
06
02
2024
medline:
11
3
2024
pubmed:
11
3
2024
entrez:
11
3
2024
Statut:
epublish
Résumé
Multifocal desmoid-type fibromatosis (DTF) is very rare and usually regional. We report three cases that initially appeared to be multifocal, but subsequent detailed imaging revealed unsuspected tracking along nerves in two cases. This neural spread is reminiscent of neuromuscular choristoma (NMC), a rare developmental lesion in which mature skeletal muscle cells, or rarely smooth muscle cells, infiltrate and enlarge peripheral nerves. NMC is frequently associated with DTF. These two cases suggest that DTF spread along nerves and appeared as distinct multifocal lesions while actually being contiguous. The third case was felt to represent true multifocal tumor development, possibly due to tumor seeding at the time of chest surgery. The relationship of DTF to NMC is discussed.
Identifiants
pubmed: 38465095
doi: 10.7759/cureus.53771
pmc: PMC10921122
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e53771Informations de copyright
Copyright © 2024, Skubitz et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.