Cervical and thoracic spinal cord gray matter atrophy is associated with disability in patients with amyotrophic lateral sclerosis.

amyotrophic lateral sclerosis imaging markers magnetic resonance imaging motor neuron diseases spinal cord imaging

Journal

European journal of neurology
ISSN: 1468-1331
Titre abrégé: Eur J Neurol
Pays: England
ID NLM: 9506311

Informations de publication

Date de publication:
11 Mar 2024
Historique:
revised: 24 01 2024
received: 12 09 2023
accepted: 14 02 2024
medline: 11 3 2024
pubmed: 11 3 2024
entrez: 11 3 2024
Statut: aheadofprint

Résumé

In amyotrophic lateral sclerosis (ALS), there is an unmet need for more precise patient characterization through quantitative, ideally operator-independent, assessments of disease extent and severity. Radially sampled averaged magnetization inversion recovery acquisitions (rAMIRA) magnetic resonance imaging enables gray matter (GM) and white matter (WM) area quantitation in the cervical and thoracic spinal cord (SC) with optimized contrast. We aimed to investigate rAMIRA-derived SC GM and SC WM areas and their association with clinical phenotype and disability in ALS. A total of 36 patients with ALS (mean [SD] age 61.7 [12.6] years, 14 women) and 36 healthy, age- and sex-matched controls (HCs; mean [SD] age 63.1 [12.1] years, 14 women) underwent two-dimensional axial rAMIRA imaging at the inter-vertebral disc levels C2/3-C5/C6 and the lumbar enlargement level T Compared to HCs, GM and WM areas were reduced in patients at all cervical levels (p < 0.0001). GM area (p = 0.0001), but not WM area, was reduced at T Patients with ALS assessed by rAMIRA imaging show significant cervical and thoracic SC GM and SC WM atrophy. SC GM area correlates with muscle strength and clinical disability. GM area reduction at T

Sections du résumé

BACKGROUND AND PURPOSE OBJECTIVE
In amyotrophic lateral sclerosis (ALS), there is an unmet need for more precise patient characterization through quantitative, ideally operator-independent, assessments of disease extent and severity. Radially sampled averaged magnetization inversion recovery acquisitions (rAMIRA) magnetic resonance imaging enables gray matter (GM) and white matter (WM) area quantitation in the cervical and thoracic spinal cord (SC) with optimized contrast. We aimed to investigate rAMIRA-derived SC GM and SC WM areas and their association with clinical phenotype and disability in ALS.
METHODS METHODS
A total of 36 patients with ALS (mean [SD] age 61.7 [12.6] years, 14 women) and 36 healthy, age- and sex-matched controls (HCs; mean [SD] age 63.1 [12.1] years, 14 women) underwent two-dimensional axial rAMIRA imaging at the inter-vertebral disc levels C2/3-C5/C6 and the lumbar enlargement level T
RESULTS RESULTS
Compared to HCs, GM and WM areas were reduced in patients at all cervical levels (p < 0.0001). GM area (p = 0.0001), but not WM area, was reduced at T
CONCLUSION CONCLUSIONS
Patients with ALS assessed by rAMIRA imaging show significant cervical and thoracic SC GM and SC WM atrophy. SC GM area correlates with muscle strength and clinical disability. GM area reduction at T

Identifiants

DOI: 10.1111/ene.16268 PMID: 38465478
pubmed: 38465478
doi: 10.1111/ene.16268
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e16268

Informations de copyright

© 2024 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.

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Auteurs

Maria Janina Wendebourg (MJ)

Department of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland.
Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Department of Biomedical Engineering, Translational Imaging in Neurology (ThINk), University of Basel, Basel, Switzerland.
Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University of Basel, Basel, Switzerland.
ORCID: 0000-0003-4812-8807

Matthias Weigel (M)

Department of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland.
Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Department of Biomedical Engineering, Translational Imaging in Neurology (ThINk), University of Basel, Basel, Switzerland.
Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University of Basel, Basel, Switzerland.
Division of Radiological Physics, Department of Radiology, University Hospital Basel, Basel, Switzerland.
Department of Biomedical Engineering, University of Basel, Basel, Switzerland.

Claudia Weidensteiner (C)

Division of Radiological Physics, Department of Radiology, University Hospital Basel, Basel, Switzerland.
Department of Biomedical Engineering, University of Basel, Basel, Switzerland.

Laura Sander (L)

Department of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland.
Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Department of Biomedical Engineering, Translational Imaging in Neurology (ThINk), University of Basel, Basel, Switzerland.
Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University of Basel, Basel, Switzerland.

Eva Kesenheimer (E)

Department of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland.
Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Department of Biomedical Engineering, Translational Imaging in Neurology (ThINk), University of Basel, Basel, Switzerland.
Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University of Basel, Basel, Switzerland.

Nicole Naumann (N)

Department of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland.

Tanja Haas (T)

Division of Radiological Physics, Department of Radiology, University Hospital Basel, Basel, Switzerland.

Philipp Madoerin (P)

Division of Radiological Physics, Department of Radiology, University Hospital Basel, Basel, Switzerland.

Nathalie Braun (N)

Neuromuscular Diseases Unit/ALS Clinic, Kantonsspital Sankt Gallen, St. Gallen, Switzerland.

Christoph Neuwirth (C)

Neuromuscular Diseases Unit/ALS Clinic, Kantonsspital Sankt Gallen, St. Gallen, Switzerland.

Markus Weber (M)

Neuromuscular Diseases Unit/ALS Clinic, Kantonsspital Sankt Gallen, St. Gallen, Switzerland.

Kathleen Jahn (K)

Clinics of Respiratory Medicine, University Hospital Basel and University of Basel, Basel, Switzerland.

Ludwig Kappos (L)

Department of Biomedical Engineering, Translational Imaging in Neurology (ThINk), University of Basel, Basel, Switzerland.
Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University of Basel, Basel, Switzerland.

Cristina Granziera (C)

Department of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland.
Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Department of Biomedical Engineering, Translational Imaging in Neurology (ThINk), University of Basel, Basel, Switzerland.
Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University of Basel, Basel, Switzerland.

Kathi Schweikert (K)

Department of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland.

Michael Sinnreich (M)

Department of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland.
Department of Biomedicine (DBE), University of Basel, Basel, Switzerland.

Oliver Bieri (O)

Division of Radiological Physics, Department of Radiology, University Hospital Basel, Basel, Switzerland.
Department of Biomedical Engineering, University of Basel, Basel, Switzerland.

Regina Schlaeger (R)

Department of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland.
Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Department of Biomedical Engineering, Translational Imaging in Neurology (ThINk), University of Basel, Basel, Switzerland.
Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University of Basel, Basel, Switzerland.
ORCID: 0000-0003-2056-5765

Classifications MeSH