Forkhead box O proteins: steering the course of stem cell fate.
Differentiation
FOXO
Quiescence
Self-renewal
Stem cell fate
Journal
Cell regeneration (London, England)
ISSN: 2045-9769
Titre abrégé: Cell Regen
Pays: China
ID NLM: 101627311
Informations de publication
Date de publication:
11 Mar 2024
11 Mar 2024
Historique:
received:
16
12
2023
accepted:
26
02
2024
medline:
11
3
2024
pubmed:
11
3
2024
entrez:
11
3
2024
Statut:
epublish
Résumé
Stem cells are pivotal players in the intricate dance of embryonic development, tissue maintenance, and regeneration. Their behavior is delicately balanced between maintaining their pluripotency and differentiating as needed. Disruptions in this balance can lead to a spectrum of diseases, underscoring the importance of unraveling the complex molecular mechanisms that govern stem cell fate. Forkhead box O (FOXO) proteins, a family of transcription factors, are at the heart of this intricate regulation, influencing a myriad of cellular processes such as survival, metabolism, and DNA repair. Their multifaceted role in steering the destiny of stem cells is evident, as they wield influence over self-renewal, quiescence, and lineage-specific differentiation in both embryonic and adult stem cells. This review delves into the structural and regulatory intricacies of FOXO transcription factors, shedding light on their pivotal roles in shaping the fate of stem cells. By providing insights into the specific functions of FOXO in determining stem cell fate, this review aims to pave the way for targeted interventions that could modulate stem cell behavior and potentially revolutionize the treatment and prevention of diseases.
Identifiants
pubmed: 38466341
doi: 10.1186/s13619-024-00190-1
pii: 10.1186/s13619-024-00190-1
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
7Subventions
Organisme : National Natural Science Foundation of China
ID : 31900330
Organisme : Natural Science Basic Research Program of Shaanxi Province
ID : 2024JC-YBMS-182
Informations de copyright
© 2024. The Author(s).
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