Closed-loop auditory stimulation of slow-wave sleep in chronic insomnia: a pilot study.
closed-loop auditory stimulation
insomnia
memory consolidation
polysomnography
slow oscillation
Journal
Journal of sleep research
ISSN: 1365-2869
Titre abrégé: J Sleep Res
Pays: England
ID NLM: 9214441
Informations de publication
Date de publication:
11 Mar 2024
11 Mar 2024
Historique:
revised:
12
12
2023
received:
22
06
2023
accepted:
07
02
2024
medline:
12
3
2024
pubmed:
12
3
2024
entrez:
11
3
2024
Statut:
aheadofprint
Résumé
Insomnia is a prevalent and disabling condition whose treatment is not always effective. This pilot study explores the feasibility and effects of closed-loop auditory stimulation (CLAS) as a potential non-invasive intervention to improve sleep, its subjective quality, and memory consolidation in patients with insomnia. A total of 27 patients with chronic insomnia underwent a crossover, sham-controlled study with 2 nights of either CLAS or sham stimulation. Polysomnography was used to record sleep parameters, while questionnaires and a word-pair memory task were administered to assess subjective sleep quality and memory consolidation. The initial analyses included 17 patients who completed the study, met the inclusion criteria, and received CLAS. From those, 10 (58%) received only a small number of stimuli. In the remaining seven (41%) patients with sufficient CLAS, we evaluated the acute and whole-night effect on sleep. CLAS led to a significant immediate increase in slow oscillation (0.5-1 Hz) amplitude and activity, and reduced delta (1-4 Hz) and sigma/sleep spindle (12-15 Hz) activity during slow-wave sleep across the whole night. All these fundamental sleep rhythms are implicated in sleep-dependent memory consolidation. Yet, CLAS did not change sleep-dependent memory consolidation or sleep macrostructure characteristics, number of arousals, or subjective perception of sleep quality. Results showed CLAS to be feasible in patients with insomnia. However, a high variance in the efficacy of our automated stimulation approach suggests that further research is needed to optimise stimulation protocols to better unlock potential CLAS benefits for sleep structure and subjective sleep quality in such clinical settings.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14179Subventions
Organisme : Ministry of Health of the Czech Republic, Czech Health Research Council
ID : NU23-04-00469
Organisme : Czech Science Foundation
ID : 22-16874S
Informations de copyright
© 2024 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society.
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