Starvation-resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity.
Journal
Life science alliance
ISSN: 2575-1077
Titre abrégé: Life Sci Alliance
Pays: United States
ID NLM: 101728869
Informations de publication
Date de publication:
May 2024
May 2024
Historique:
received:
26
10
2023
revised:
14
02
2024
accepted:
19
02
2024
medline:
12
3
2024
pubmed:
12
3
2024
entrez:
11
3
2024
Statut:
epublish
Résumé
Starvation causes the accumulation of lipid droplets in the liver, a somewhat counterintuitive phenomenon that is nevertheless conserved from flies to humans. Much like fatty liver resulting from overfeeding, hepatic lipid accumulation (steatosis) during undernourishment can lead to lipotoxicity and atrophy of the liver. Here, we found that although surface populations of
Identifiants
pubmed: 38467419
pii: 7/5/e202302458
doi: 10.26508/lsa.202302458
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024 Pozo-Morales et al.