Cdc73 is a major regulator of apoptosis-inducing factor 1 expression in Saccharomyces cerevisiae via H3K36 methylation.
AIF1
histone modifications
hydrogen peroxide
transcription factors
Journal
FEBS letters
ISSN: 1873-3468
Titre abrégé: FEBS Lett
Pays: England
ID NLM: 0155157
Informations de publication
Date de publication:
11 Mar 2024
11 Mar 2024
Historique:
revised:
18
01
2024
received:
09
11
2023
accepted:
09
02
2024
medline:
12
3
2024
pubmed:
12
3
2024
entrez:
11
3
2024
Statut:
aheadofprint
Résumé
Apoptosis-inducing factor 1 (AIF1) overexpression is intimately linked to the sensitivity of yeast cells towards hydrogen peroxide or acetic acid. Therefore, studying the mechanism of AIF1 regulation in the cell would provide a significant understanding of the factors guiding yeast apoptosis. In this report, we show the time-dependent induction of AIF1 under hydrogen peroxide stress. Additionally, we find that AIF1 expression in response to hydrogen peroxide is mediated by two transcription factors, Yap5 (DNA binding) and Cdc73 (non-DNA binding). Furthermore, substituting the H3K36 residue with another amino acid significantly abrogates AIF1 expression. However, substituting the lysine (K) in H3K4 or H3K79 with alanine (A) does not affect AIF1 expression level under hydrogen peroxide stress. Altogether, reduced AIF1 expression in cdc73Δ is plausibly due to reduced H3K36me3 levels in the cells.
Identifiants
pubmed: 38467538
doi: 10.1002/1873-3468.14847
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Council of Scientific and Industrial Research, India
ID : 38(1438)/18/EMR-II
Informations de copyright
© 2024 Federation of European Biochemical Societies.
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