An organism-wide atlas of hormonal signaling based on the mouse lemur single-cell transcriptome.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
11 Mar 2024
11 Mar 2024
Historique:
received:
16
08
2022
accepted:
07
02
2024
medline:
12
3
2024
pubmed:
12
3
2024
entrez:
12
3
2024
Statut:
epublish
Résumé
Hormones mediate long-range cell communication and play vital roles in physiology, metabolism, and health. Traditionally, endocrinologists have focused on one hormone or organ system at a time. Yet, hormone signaling by its very nature connects cells of different organs and involves crosstalk of different hormones. Here, we leverage the organism-wide single cell transcriptional atlas of a non-human primate, the mouse lemur (Microcebus murinus), to systematically map source and target cells for 84 classes of hormones. This work uncovers previously-uncharacterized sites of hormone regulation, and shows that the hormonal signaling network is densely connected, decentralized, and rich in feedback loops. Evolutionary comparisons of hormonal genes and their expression patterns show that mouse lemur better models human hormonal signaling than mouse, at both the genomic and transcriptomic levels, and reveal primate-specific rewiring of hormone-producing/target cells. This work complements the scale and resolution of classical endocrine studies and sheds light on primate hormone regulation.
Identifiants
pubmed: 38467625
doi: 10.1038/s41467-024-46070-9
pii: 10.1038/s41467-024-46070-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2188Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM131792
Pays : United States
Investigateurs
Snigdha Agarwal
(S)
Aditi Agrawal
(A)
Ahmad Al-Moujahed
(A)
Alina Alam
(A)
Megan A Albertelli
(MA)
Paul Allegakoen
(P)
Thomas Ambrosi
(T)
Jane Antony
(J)
Steven Artandi
(S)
Fabienne Aujard
(F)
Ankit Baghel
(A)
Isaac Bakerman
(I)
Trygve E Bakken
(TE)
Jalal Baruni
(J)
Philip Beachy
(P)
Biter Bilen
(B)
Olga Botvinnik
(O)
Scott D Boyd
(SD)
Deviana Burhan
(D)
Kerriann M Casey
(KM)
Charles Chan
(C)
Charles A Chang
(CA)
Stephen Chang
(S)
Ming Chen
(M)
Michael F Clarke
(MF)
Sheela Crasta
(S)
Rebecca Culver
(R)
Jessica D'Addabbo
(J)
Spyros Darmanis
(S)
Roozbeh Dehghannasiri
(R)
Song-Lin Ding
(SL)
Connor V Duffy
(CV)
F Hernán Espinoza
(FH)
Jean Farup
(J)
Hannah K Frank
(HK)
Margaret Fuller
(M)
Astrid Gillich
(A)
Elias Godoy
(E)
Dita Gratzinger
(D)
Lisbeth A Guethlein
(LA)
Yan Hang
(Y)
Kazuteru Hasegawa
(K)
Rebecca D Hodge
(RD)
Malachia Hoover
(M)
Franklin W Huang
(FW)
Kerwyn C Huang
(KC)
Shelly Huynh
(S)
Taichi Isobe
(T)
Carly Israel
(C)
SoRi Jang
(S)
Qiuyu Jing
(Q)
Robert C Jones
(RC)
Jengmin Kang
(J)
Caitlin J Karanewsky
(CJ)
Jim Karkanias
(J)
Justus Kebschull
(J)
Aaron Kershner
(A)
Lily Kim
(L)
Seung K Kim
(SK)
E Christopher Kirk
(EC)
Winston Koh
(W)
Silvana Konermann
(S)
William Kong
(W)
Corinne Lautier
(C)
Song Eun Lee
(SE)
Ed S Lein
(ES)
Rebecca Lewis
(R)
Peng Li
(P)
Shengda Lin
(S)
Yin Liu
(Y)
Gabriel Loeb
(G)
Wan-Jin Lu
(WJ)
Katherine Lucot
(K)
Liqun Luo
(L)
Ashley Maynard
(A)
Aaron McGeever
(A)
Ross Metzger
(R)
Jingsi Ming
(J)
Tom Montine
(T)
Antoine de Morree
(A)
Maurizio Morri
(M)
Karim Mrouj
(K)
Shravani Mukherjee
(S)
Ahmad Nabhan
(A)
Saba Nafees
(S)
Norma Neff
(N)
Patrick Neuhöfer
(P)
Patricia Nguyen
(P)
Jennifer Okamoto
(J)
Julia Olivieri
(J)
Youcef Ouadah
(Y)
Honor Paine
(H)
Peter Parham
(P)
Jozeph L Pendleton
(JL)
Lolita Penland
(L)
Martine Perret
(M)
Angela Oliveira Pisco
(AO)
Zhen Qi
(Z)
Stephen R Quake
(SR)
Ute Radespiel
(U)
Thomas A Rando
(TA)
Hajanirina Noëline Ravelonjanahary
(H)
Andriamahery Razafindrakoto
(A)
Julia Salzman
(J)
Nicholas Schaum
(N)
Robert Schopler
(R)
Bronwyn Scott
(B)
Liza Shapiro
(L)
Hosu Sin
(H)
Rahul Sinha
(R)
Rene Sit
(R)
Geoff Stanley
(G)
Lubert Stryer
(L)
Varun Ramanan Subramaniam
(VR)
Aditi Swarup
(A)
Michelle Tan
(M)
Weilun Tan
(W)
Alexander Tarashansky
(A)
Aris Taychameekiatchai
(A)
Kyle J Travaglini
(KJ)
Andoni Urtasun
(A)
None Sivakamasundari
Avin Veerakumar
(A)
Venkata N P Vemuri
(VNP)
Jean-Michel Verdier
(JM)
Douglas Vollrath
(D)
Bo Wang
(B)
Bruce Wang
(B)
Gefei Wang
(G)
James Webber
(J)
Hannah Weinstein
(H)
Irving L Weissman
(IL)
Amanda L Wiggenhorn
(AL)
Cathy V Williams
(CV)
Patricia Wright
(P)
Albert Y Wu
(AY)
Angela Ruohao Wu
(AR)
Timothy Ting-Hsuan Wu
(TT)
Tony Wyss-Coray
(T)
BaoXiang Li
(B)
Jia Yan
(J)
Can Yang
(C)
Jinxurong Yang
(J)
Anne D Yoder
(AD)
Brian Yu
(B)
Andrea R Yung
(AR)
Yue Zhang
(Y)
Jia Zhao
(J)
Zicheng Zhao
(Z)
Informations de copyright
© 2024. The Author(s).
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