The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
11 Mar 2024
11 Mar 2024
Historique:
received:
20
04
2023
accepted:
26
02
2024
medline:
12
3
2024
pubmed:
12
3
2024
entrez:
12
3
2024
Statut:
epublish
Résumé
The regulation of thymocyte development by RNA-binding proteins (RBPs) is largely unexplored. We identify 642 RBPs in the thymus and focus on Arpp21, which shows selective and dynamic expression in early thymocytes. Arpp21 is downregulated in response to T cell receptor (TCR) and Ca
Identifiants
pubmed: 38467629
doi: 10.1038/s41467-024-46371-z
pii: 10.1038/s41467-024-46371-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2194Subventions
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : SFB 1054 # 210592381
Informations de copyright
© 2024. The Author(s).
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