Palaeoproteomic investigation of an ancient human skeleton with abnormal deposition of dental calculus.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
11 Mar 2024
11 Mar 2024
Historique:
received:
03
08
2023
accepted:
27
02
2024
medline:
12
3
2024
pubmed:
12
3
2024
entrez:
12
3
2024
Statut:
epublish
Résumé
Detailed investigation of extremely severe pathological conditions in ancient human skeletons is important as it could shed light on the breadth of potential interactions between humans and disease etiologies in the past. Here, we applied palaeoproteomics to investigate an ancient human skeletal individual with severe oral pathology, focusing our research on bacterial pathogenic factors and host defense response. This female skeleton, from the Okhotsk period (i.e., fifth to thirteenth century) of Northern Japan, poses relevant amounts of abnormal dental calculus deposition and exhibits oral dysfunction due to severe periodontal disease. A shotgun mass-spectrometry analysis identified 81 human proteins and 15 bacterial proteins from the calculus of the subject. We identified two pathogenic or bioinvasive proteins originating from two of the three "red complex" bacteria, the core species associated with severe periodontal disease in modern humans, as well as two additional bioinvasive proteins of periodontal-associated bacteria. Moreover, we discovered defense response system-associated human proteins, although their proportion was mostly similar to those reported in ancient and modern human individuals with lower calculus deposition. These results suggest that the bacterial etiology was similar and the host defense response was not necessarily more intense in ancient individuals with significant amounts of abnormal dental calculus deposition.
Identifiants
pubmed: 38467689
doi: 10.1038/s41598-024-55779-y
pii: 10.1038/s41598-024-55779-y
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5938Subventions
Organisme : Japan Society for the Promotion of Science
ID : 19K01134
Organisme : Japan Society for the Promotion of Science
ID : 19K06868
Organisme : Japan Society for the Promotion of Science
ID : 20H01370
Organisme : Japan Society for the Promotion of Science
ID : 20KK0166
Organisme : Japan Society for the Promotion of Science
ID : 23H00032
Organisme : Japan Society for the Promotion of Science
ID : 22KK0170
Organisme : Japan Society for the Promotion of Science
ID : 20H05821
Organisme : Japan Society for the Promotion of Science
ID : 16H06408
Organisme : Japan Society for the Promotion of Science
ID : 21H00588
Informations de copyright
© 2024. The Author(s).
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